Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in human immunodeficiency virus infection

Homer Twigg, Diaa M. Soliman, Richard B. Day, Kenneth S. Knox, Rodney J. Anderson, David S. Wilkes, Carol T. Schnizlein-Bick

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Lymphocytic alveolitis portends a poor prognosis in human immunodeficiency virus (HIV)-infected subjects. Because alveolar lymphocytes consist predominantly of HIV-specific CD8+ cytotoxic T lymphocytes (CTL), they could represent an appropriate immune response to infected cells in the lung, and be a surrogate marker for a high pulmonary vital burden. We assessed long-term outcome in a cohort of asymptomatic HIV-infected subjects who underwent bronchoscopy between 1990 and 1993 and had bronchoalveolar lavage fluid (BALF) available for determination of vital load by reverse transcription-polymerase chain reaction. The ability to detect HIV in BALF increased with disease progression. Lymphocytic alveolitis, although present at all stages of HIV infection, was most pronounced in patients with middle stage disease. The HIV viral load as measured by bronchoalveolar lavage correlated with the percentage of alveolar lymphocytes in patients with peripheral blood CD4+ cell counts above 200/μl. Including patients with CD4+ cell counts < 200/μl weakened this correlation, possibly because of replacement of CD8+ CTL by CD8+ suppressor cells in advanced disease. Free virus in BALF was a stronger predictor of HIV disease progression than was lymphocytic alveolitis. These data suggest that lymphocytic alveolitis in HIV-infected subjects occurs in response to viral antigens in the lung and that the poor prognosis associated with lymphocytic alveolitis reflects a high pulmonary viral burden.

Original languageEnglish
Pages (from-to)1439-1444
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume159
Issue number5 I
StatePublished - 1999

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Bronchoalveolar Lavage
Virus Diseases
Viral Load
HIV
Bronchoalveolar Lavage Fluid
Lung
Cytotoxic T-Lymphocytes
CD4 Lymphocyte Count
Disease Progression
Lymphocytes
Blood Cell Count
Viral Antigens
Bronchoscopy
Reverse Transcription
Biomarkers
Viruses
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Twigg, H., Soliman, D. M., Day, R. B., Knox, K. S., Anderson, R. J., Wilkes, D. S., & Schnizlein-Bick, C. T. (1999). Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in human immunodeficiency virus infection. American Journal of Respiratory and Critical Care Medicine, 159(5 I), 1439-1444.

Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in human immunodeficiency virus infection. / Twigg, Homer; Soliman, Diaa M.; Day, Richard B.; Knox, Kenneth S.; Anderson, Rodney J.; Wilkes, David S.; Schnizlein-Bick, Carol T.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 159, No. 5 I, 1999, p. 1439-1444.

Research output: Contribution to journalArticle

Twigg, H, Soliman, DM, Day, RB, Knox, KS, Anderson, RJ, Wilkes, DS & Schnizlein-Bick, CT 1999, 'Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in human immunodeficiency virus infection', American Journal of Respiratory and Critical Care Medicine, vol. 159, no. 5 I, pp. 1439-1444.
Twigg, Homer ; Soliman, Diaa M. ; Day, Richard B. ; Knox, Kenneth S. ; Anderson, Rodney J. ; Wilkes, David S. ; Schnizlein-Bick, Carol T. / Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in human immunodeficiency virus infection. In: American Journal of Respiratory and Critical Care Medicine. 1999 ; Vol. 159, No. 5 I. pp. 1439-1444.
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