Lymphocytic interstitial pneumonitis, elevated IgM concentration, and hepatosplenomegaly in ataxia-telangiectasia

Nutthapong Tangsinmankong, Alan S. Wayne, Michelle Howenstine, Kenneth R. Washington, Claire Langston, Richard A. Gatti, Robert A. Good, Robert Nelson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An 8-year-old girl developed ataxia-telangiectasia. Western blotting of lysate revealed absence of the ATM protein, and 2 mutations in the ATM gene were found. Subsequently, the patient developed increased respiratory symptoms. Open lung biopsy revealed lymphocytic interstitial pneumonitis, which is not characteristic of ataxia-telangiectasia. There was a therapeutic response to glucocorticosteroid treatment.

Original languageEnglish
Pages (from-to)939-941
Number of pages3
JournalJournal of Pediatrics
Volume138
Issue number6
DOIs
StatePublished - 2001

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Ataxia Telangiectasia
Interstitial Lung Diseases
Immunoglobulin M
Ataxia Telangiectasia Mutated Proteins
Western Blotting
Biopsy
Lung
Mutation
Therapeutics
Genes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Lymphocytic interstitial pneumonitis, elevated IgM concentration, and hepatosplenomegaly in ataxia-telangiectasia. / Tangsinmankong, Nutthapong; Wayne, Alan S.; Howenstine, Michelle; Washington, Kenneth R.; Langston, Claire; Gatti, Richard A.; Good, Robert A.; Nelson, Robert.

In: Journal of Pediatrics, Vol. 138, No. 6, 2001, p. 939-941.

Research output: Contribution to journalArticle

Tangsinmankong, Nutthapong ; Wayne, Alan S. ; Howenstine, Michelle ; Washington, Kenneth R. ; Langston, Claire ; Gatti, Richard A. ; Good, Robert A. ; Nelson, Robert. / Lymphocytic interstitial pneumonitis, elevated IgM concentration, and hepatosplenomegaly in ataxia-telangiectasia. In: Journal of Pediatrics. 2001 ; Vol. 138, No. 6. pp. 939-941.
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