Lymphocytic interstitial pneumonitis, elevated IgM concentration, and hepatosplenomegaly in ataxia-telangiectasia

Nutthapong Tangsinmankong, Alan S. Wayne, Michelle S. Howenstine, Kenneth R. Washington, Claire Langston, Richard A. Gatti, Robert A. Good, Robert P. Nelson

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

An 8-year-old girl developed ataxia-telangiectasia. Western blotting of lysate revealed absence of the ATM protein, and 2 mutations in the ATM gene were found. Subsequently, the patient developed increased respiratory symptoms. Open lung biopsy revealed lymphocytic interstitial pneumonitis, which is not characteristic of ataxia-telangiectasia. There was a therapeutic response to glucocorticosteroid treatment.

Original languageEnglish (US)
Pages (from-to)939-941
Number of pages3
JournalJournal of Pediatrics
Volume138
Issue number6
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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