Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection

Yang Lin, Mervin Yoder, Momoko Yoshimoto

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Mammalian embryos produce several waves of hematopoietic cells before the establishment of the hematopoietic stem cell (HSC) hierarchy. These early waves of embryonic hematopoiesis present a reversed hierarchy in which hematopoietic potential is first displayed by highly specialized cells that are derived from transient uni- and bipotent progenitor cells. Hematopoiesis progresses through multilineage erythro-myeloid progenitor cells that lack self-renewal potential and, subsequently, to make distinct lymphoid progenitor cells before culminating in detectable definitive HSC. This review provides an overview of the stepwise development of embryonic hematopoiesis. We focus on recent progress in demonstrating that lymphoid lineages emerge from hemogenic endothelial cells before the presence of definitive HSC activity and discuss the implications of these findings.

Original languageEnglish
Pages (from-to)1168-1177
Number of pages10
JournalStem Cells and Development
Volume23
Issue number11
DOIs
StatePublished - Jun 1 2014

Fingerprint

Yolk Sac
Hematopoiesis
Hematopoietic Stem Cells
Stem Cells
Embryonic Structures
Hemangioblasts
Lymphoid Progenitor Cells
Mammalian Embryo
Myeloid Progenitor Cells
Embryonic Development

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Hematology
  • Medicine(all)

Cite this

Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection. / Lin, Yang; Yoder, Mervin; Yoshimoto, Momoko.

In: Stem Cells and Development, Vol. 23, No. 11, 01.06.2014, p. 1168-1177.

Research output: Contribution to journalArticle

@article{1652f10946a44a17932520e2d6bd607f,
title = "Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection",
abstract = "Mammalian embryos produce several waves of hematopoietic cells before the establishment of the hematopoietic stem cell (HSC) hierarchy. These early waves of embryonic hematopoiesis present a reversed hierarchy in which hematopoietic potential is first displayed by highly specialized cells that are derived from transient uni- and bipotent progenitor cells. Hematopoiesis progresses through multilineage erythro-myeloid progenitor cells that lack self-renewal potential and, subsequently, to make distinct lymphoid progenitor cells before culminating in detectable definitive HSC. This review provides an overview of the stepwise development of embryonic hematopoiesis. We focus on recent progress in demonstrating that lymphoid lineages emerge from hemogenic endothelial cells before the presence of definitive HSC activity and discuss the implications of these findings.",
author = "Yang Lin and Mervin Yoder and Momoko Yoshimoto",
year = "2014",
month = "6",
day = "1",
doi = "10.1089/scd.2013.0536",
language = "English",
volume = "23",
pages = "1168--1177",
journal = "Stem Cells and Development",
issn = "1547-3287",
publisher = "Mary Ann Liebert Inc.",
number = "11",

}

TY - JOUR

T1 - Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection

AU - Lin, Yang

AU - Yoder, Mervin

AU - Yoshimoto, Momoko

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Mammalian embryos produce several waves of hematopoietic cells before the establishment of the hematopoietic stem cell (HSC) hierarchy. These early waves of embryonic hematopoiesis present a reversed hierarchy in which hematopoietic potential is first displayed by highly specialized cells that are derived from transient uni- and bipotent progenitor cells. Hematopoiesis progresses through multilineage erythro-myeloid progenitor cells that lack self-renewal potential and, subsequently, to make distinct lymphoid progenitor cells before culminating in detectable definitive HSC. This review provides an overview of the stepwise development of embryonic hematopoiesis. We focus on recent progress in demonstrating that lymphoid lineages emerge from hemogenic endothelial cells before the presence of definitive HSC activity and discuss the implications of these findings.

AB - Mammalian embryos produce several waves of hematopoietic cells before the establishment of the hematopoietic stem cell (HSC) hierarchy. These early waves of embryonic hematopoiesis present a reversed hierarchy in which hematopoietic potential is first displayed by highly specialized cells that are derived from transient uni- and bipotent progenitor cells. Hematopoiesis progresses through multilineage erythro-myeloid progenitor cells that lack self-renewal potential and, subsequently, to make distinct lymphoid progenitor cells before culminating in detectable definitive HSC. This review provides an overview of the stepwise development of embryonic hematopoiesis. We focus on recent progress in demonstrating that lymphoid lineages emerge from hemogenic endothelial cells before the presence of definitive HSC activity and discuss the implications of these findings.

UR - http://www.scopus.com/inward/record.url?scp=84901309496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901309496&partnerID=8YFLogxK

U2 - 10.1089/scd.2013.0536

DO - 10.1089/scd.2013.0536

M3 - Article

C2 - 24417306

AN - SCOPUS:84901309496

VL - 23

SP - 1168

EP - 1177

JO - Stem Cells and Development

JF - Stem Cells and Development

SN - 1547-3287

IS - 11

ER -