Abstract
Mammalian embryos produce several waves of hematopoietic cells before the establishment of the hematopoietic stem cell (HSC) hierarchy. These early waves of embryonic hematopoiesis present a reversed hierarchy in which hematopoietic potential is first displayed by highly specialized cells that are derived from transient uni- and bipotent progenitor cells. Hematopoiesis progresses through multilineage erythro-myeloid progenitor cells that lack self-renewal potential and, subsequently, to make distinct lymphoid progenitor cells before culminating in detectable definitive HSC. This review provides an overview of the stepwise development of embryonic hematopoiesis. We focus on recent progress in demonstrating that lymphoid lineages emerge from hemogenic endothelial cells before the presence of definitive HSC activity and discuss the implications of these findings.
| Original language | English |
|---|---|
| Pages (from-to) | 1168-1177 |
| Number of pages | 10 |
| Journal | Stem Cells and Development |
| Volume | 23 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 1 2014 |
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ASJC Scopus subject areas
- Cell Biology
- Developmental Biology
- Hematology
- Medicine(all)
Cite this
Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection. / Lin, Yang; Yoder, Mervin; Yoshimoto, Momoko.
In: Stem Cells and Development, Vol. 23, No. 11, 01.06.2014, p. 1168-1177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection
AU - Lin, Yang
AU - Yoder, Mervin
AU - Yoshimoto, Momoko
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Mammalian embryos produce several waves of hematopoietic cells before the establishment of the hematopoietic stem cell (HSC) hierarchy. These early waves of embryonic hematopoiesis present a reversed hierarchy in which hematopoietic potential is first displayed by highly specialized cells that are derived from transient uni- and bipotent progenitor cells. Hematopoiesis progresses through multilineage erythro-myeloid progenitor cells that lack self-renewal potential and, subsequently, to make distinct lymphoid progenitor cells before culminating in detectable definitive HSC. This review provides an overview of the stepwise development of embryonic hematopoiesis. We focus on recent progress in demonstrating that lymphoid lineages emerge from hemogenic endothelial cells before the presence of definitive HSC activity and discuss the implications of these findings.
AB - Mammalian embryos produce several waves of hematopoietic cells before the establishment of the hematopoietic stem cell (HSC) hierarchy. These early waves of embryonic hematopoiesis present a reversed hierarchy in which hematopoietic potential is first displayed by highly specialized cells that are derived from transient uni- and bipotent progenitor cells. Hematopoiesis progresses through multilineage erythro-myeloid progenitor cells that lack self-renewal potential and, subsequently, to make distinct lymphoid progenitor cells before culminating in detectable definitive HSC. This review provides an overview of the stepwise development of embryonic hematopoiesis. We focus on recent progress in demonstrating that lymphoid lineages emerge from hemogenic endothelial cells before the presence of definitive HSC activity and discuss the implications of these findings.
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U2 - 10.1089/scd.2013.0536
DO - 10.1089/scd.2013.0536
M3 - Article
VL - 23
SP - 1168
EP - 1177
JO - Stem Cells and Development
JF - Stem Cells and Development
SN - 1547-3287
IS - 11
ER -