Abstract
Merkel cell carcinoma (MCC) is a rare cutaneous malignancy characterized by an aggressive clinical behavior with high rates of locoregional and systemic recurrence. Regional disease and distant metastases are associated with poor prognosis. Despite a predisposition of MCC to spread via the lymphatics, prophylactic lymph node dissection in the absence of clinically apparent lymph node involvement is controversial. The value of lymphoscintigraphy in cutaneous melanoma is established in lesions with ambiguous lymphatic drainage patterns. When used with sentinel lymph node biopsy (SLNB), it can identify subjects with occult regional node metastasis. The authors present 2 patients with MCC who underwent regional node staging with lymphoscintigraphy-directed SLNB. Both patients had sentinel nodes that were positive for metastatic disease. In patients with MCC, minimally invasive regional node staging SLNB may be useful in limiting the sequelae of routine lymphadenectomies. Whether early identification and treatment of patients with occult regional node disease can influence survival in MCC is not known.
| Original language | English |
|---|---|
| Pages (from-to) | 679-682 |
| Number of pages | 4 |
| Journal | Annals of Plastic Surgery |
| Volume | 42 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1999 |
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ASJC Scopus subject areas
- Surgery
Cite this
Lymphoscintigraphy with sentinel lymph node biopsy in cutaneous merkel cell carcinoma. / Sian, Kenty U.; Wagner, Jeffrey D.; Sood, Rajiv; Park, Hee Myung; Havlik, Robert; Coleman, John J.
In: Annals of Plastic Surgery, Vol. 42, No. 6, 06.1999, p. 679-682.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphoscintigraphy with sentinel lymph node biopsy in cutaneous merkel cell carcinoma
AU - Sian, Kenty U.
AU - Wagner, Jeffrey D.
AU - Sood, Rajiv
AU - Park, Hee Myung
AU - Havlik, Robert
AU - Coleman, John J.
PY - 1999/6
Y1 - 1999/6
N2 - Merkel cell carcinoma (MCC) is a rare cutaneous malignancy characterized by an aggressive clinical behavior with high rates of locoregional and systemic recurrence. Regional disease and distant metastases are associated with poor prognosis. Despite a predisposition of MCC to spread via the lymphatics, prophylactic lymph node dissection in the absence of clinically apparent lymph node involvement is controversial. The value of lymphoscintigraphy in cutaneous melanoma is established in lesions with ambiguous lymphatic drainage patterns. When used with sentinel lymph node biopsy (SLNB), it can identify subjects with occult regional node metastasis. The authors present 2 patients with MCC who underwent regional node staging with lymphoscintigraphy-directed SLNB. Both patients had sentinel nodes that were positive for metastatic disease. In patients with MCC, minimally invasive regional node staging SLNB may be useful in limiting the sequelae of routine lymphadenectomies. Whether early identification and treatment of patients with occult regional node disease can influence survival in MCC is not known.
AB - Merkel cell carcinoma (MCC) is a rare cutaneous malignancy characterized by an aggressive clinical behavior with high rates of locoregional and systemic recurrence. Regional disease and distant metastases are associated with poor prognosis. Despite a predisposition of MCC to spread via the lymphatics, prophylactic lymph node dissection in the absence of clinically apparent lymph node involvement is controversial. The value of lymphoscintigraphy in cutaneous melanoma is established in lesions with ambiguous lymphatic drainage patterns. When used with sentinel lymph node biopsy (SLNB), it can identify subjects with occult regional node metastasis. The authors present 2 patients with MCC who underwent regional node staging with lymphoscintigraphy-directed SLNB. Both patients had sentinel nodes that were positive for metastatic disease. In patients with MCC, minimally invasive regional node staging SLNB may be useful in limiting the sequelae of routine lymphadenectomies. Whether early identification and treatment of patients with occult regional node disease can influence survival in MCC is not known.
UR - http://www.scopus.com/inward/record.url?scp=0032982957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032982957&partnerID=8YFLogxK
U2 - 10.1097/00000637-199906000-00017
DO - 10.1097/00000637-199906000-00017
M3 - Article
C2 - 10382808
AN - SCOPUS:0032982957
VL - 42
SP - 679
EP - 682
JO - Annals of Plastic Surgery
JF - Annals of Plastic Surgery
SN - 0148-7043
IS - 6
ER -