Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma

Liang Cheng, Timothy D. Jones, Haiqun Lin, John Eble, Gordon Zeng, Matthew D. Carr, Michael Koch

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Purpose: Gleason grade and tumor stage are well established prognostic factors in prostate cancer. Histological demonstration of tumor in lymphovascular spaces has been associated with poor prognosis in many tumor types but it is not included in current prostate cancer grading and staging schemes. Whether lymphovascular invasion is an independent prognostic factor for disease progression in prostate cancer is uncertain. We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy. Materials and Methods: The records of 504 patients with prostatic adenocarcinoma undergoing radical prostatectomy were reviewed for lymphovascular invasion. Clinical followup data were available on 459 cases. Mean followup was 44 months (range 1.5 to 144). Multivariate analysis was performed using the Cox model. Results: Lymphovascular invasion was identified in 106 cases (21%). Univariate analysis showed a significant association between lymphovascular invasion and higher preoperative serum prostate specific antigen (PSA), advanced pathological stage, higher Gleason score, positive surgical margins, extraprostatic extension, seminal vesicle invasion, lymph node metastasis and perineural invasion (each p <0.001). No association was observed between lymphovascular invasion and patient age at surgery, prostate weight or high grade prostatic intraepithelial neoplasia. Lymphovascular invasion was an independent predictor of PSA recurrence (HR 1.6, 95% CI 1.12 to 2.38, p = 0.01) and cancer specific survival (HR 2.75, 95% CI 1.04 to 2.28, p = 0.041) after controlling for tumor stage, surreal margins and Gleason grade on multivariate analysis. Five-year cancer specific survival was 90% in men with lymphovascular invasion compared to 98% in those without lymphovascular invasion (p <0.001). Conclusions: Lymphovascular invasion can be identified in approximately 20% of prostate cancer cases. Lymphovascular invasion is an independent risk factor for PSA recurrence and cancer death in patients with prostate cancer.

Original languageEnglish
Pages (from-to)2181-2185
Number of pages5
JournalJournal of Urology
Volume174
Issue number6
DOIs
StatePublished - Dec 2005

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Adenocarcinoma
Prostatic Neoplasms
Neoplasms
Prostate-Specific Antigen
Prostatectomy
Survival
Multivariate Analysis
Prostatic Intraepithelial Neoplasia
Recurrence
Neoplasm Grading
Seminal Vesicles
Neoplasm Staging
Proportional Hazards Models
Disease Progression
Prostate
Lymph Nodes
Neoplasm Metastasis
Weights and Measures
Serum

Keywords

  • Disease progression
  • Neoplasm invasiveness
  • Prostate
  • Prostatectomy
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma. / Cheng, Liang; Jones, Timothy D.; Lin, Haiqun; Eble, John; Zeng, Gordon; Carr, Matthew D.; Koch, Michael.

In: Journal of Urology, Vol. 174, No. 6, 12.2005, p. 2181-2185.

Research output: Contribution to journalArticle

Cheng, Liang ; Jones, Timothy D. ; Lin, Haiqun ; Eble, John ; Zeng, Gordon ; Carr, Matthew D. ; Koch, Michael. / Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma. In: Journal of Urology. 2005 ; Vol. 174, No. 6. pp. 2181-2185.
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abstract = "Purpose: Gleason grade and tumor stage are well established prognostic factors in prostate cancer. Histological demonstration of tumor in lymphovascular spaces has been associated with poor prognosis in many tumor types but it is not included in current prostate cancer grading and staging schemes. Whether lymphovascular invasion is an independent prognostic factor for disease progression in prostate cancer is uncertain. We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy. Materials and Methods: The records of 504 patients with prostatic adenocarcinoma undergoing radical prostatectomy were reviewed for lymphovascular invasion. Clinical followup data were available on 459 cases. Mean followup was 44 months (range 1.5 to 144). Multivariate analysis was performed using the Cox model. Results: Lymphovascular invasion was identified in 106 cases (21{\%}). Univariate analysis showed a significant association between lymphovascular invasion and higher preoperative serum prostate specific antigen (PSA), advanced pathological stage, higher Gleason score, positive surgical margins, extraprostatic extension, seminal vesicle invasion, lymph node metastasis and perineural invasion (each p <0.001). No association was observed between lymphovascular invasion and patient age at surgery, prostate weight or high grade prostatic intraepithelial neoplasia. Lymphovascular invasion was an independent predictor of PSA recurrence (HR 1.6, 95{\%} CI 1.12 to 2.38, p = 0.01) and cancer specific survival (HR 2.75, 95{\%} CI 1.04 to 2.28, p = 0.041) after controlling for tumor stage, surreal margins and Gleason grade on multivariate analysis. Five-year cancer specific survival was 90{\%} in men with lymphovascular invasion compared to 98{\%} in those without lymphovascular invasion (p <0.001). Conclusions: Lymphovascular invasion can be identified in approximately 20{\%} of prostate cancer cases. Lymphovascular invasion is an independent risk factor for PSA recurrence and cancer death in patients with prostate cancer.",
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T1 - Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma

AU - Cheng, Liang

AU - Jones, Timothy D.

AU - Lin, Haiqun

AU - Eble, John

AU - Zeng, Gordon

AU - Carr, Matthew D.

AU - Koch, Michael

PY - 2005/12

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N2 - Purpose: Gleason grade and tumor stage are well established prognostic factors in prostate cancer. Histological demonstration of tumor in lymphovascular spaces has been associated with poor prognosis in many tumor types but it is not included in current prostate cancer grading and staging schemes. Whether lymphovascular invasion is an independent prognostic factor for disease progression in prostate cancer is uncertain. We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy. Materials and Methods: The records of 504 patients with prostatic adenocarcinoma undergoing radical prostatectomy were reviewed for lymphovascular invasion. Clinical followup data were available on 459 cases. Mean followup was 44 months (range 1.5 to 144). Multivariate analysis was performed using the Cox model. Results: Lymphovascular invasion was identified in 106 cases (21%). Univariate analysis showed a significant association between lymphovascular invasion and higher preoperative serum prostate specific antigen (PSA), advanced pathological stage, higher Gleason score, positive surgical margins, extraprostatic extension, seminal vesicle invasion, lymph node metastasis and perineural invasion (each p <0.001). No association was observed between lymphovascular invasion and patient age at surgery, prostate weight or high grade prostatic intraepithelial neoplasia. Lymphovascular invasion was an independent predictor of PSA recurrence (HR 1.6, 95% CI 1.12 to 2.38, p = 0.01) and cancer specific survival (HR 2.75, 95% CI 1.04 to 2.28, p = 0.041) after controlling for tumor stage, surreal margins and Gleason grade on multivariate analysis. Five-year cancer specific survival was 90% in men with lymphovascular invasion compared to 98% in those without lymphovascular invasion (p <0.001). Conclusions: Lymphovascular invasion can be identified in approximately 20% of prostate cancer cases. Lymphovascular invasion is an independent risk factor for PSA recurrence and cancer death in patients with prostate cancer.

AB - Purpose: Gleason grade and tumor stage are well established prognostic factors in prostate cancer. Histological demonstration of tumor in lymphovascular spaces has been associated with poor prognosis in many tumor types but it is not included in current prostate cancer grading and staging schemes. Whether lymphovascular invasion is an independent prognostic factor for disease progression in prostate cancer is uncertain. We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy. Materials and Methods: The records of 504 patients with prostatic adenocarcinoma undergoing radical prostatectomy were reviewed for lymphovascular invasion. Clinical followup data were available on 459 cases. Mean followup was 44 months (range 1.5 to 144). Multivariate analysis was performed using the Cox model. Results: Lymphovascular invasion was identified in 106 cases (21%). Univariate analysis showed a significant association between lymphovascular invasion and higher preoperative serum prostate specific antigen (PSA), advanced pathological stage, higher Gleason score, positive surgical margins, extraprostatic extension, seminal vesicle invasion, lymph node metastasis and perineural invasion (each p <0.001). No association was observed between lymphovascular invasion and patient age at surgery, prostate weight or high grade prostatic intraepithelial neoplasia. Lymphovascular invasion was an independent predictor of PSA recurrence (HR 1.6, 95% CI 1.12 to 2.38, p = 0.01) and cancer specific survival (HR 2.75, 95% CI 1.04 to 2.28, p = 0.041) after controlling for tumor stage, surreal margins and Gleason grade on multivariate analysis. Five-year cancer specific survival was 90% in men with lymphovascular invasion compared to 98% in those without lymphovascular invasion (p <0.001). Conclusions: Lymphovascular invasion can be identified in approximately 20% of prostate cancer cases. Lymphovascular invasion is an independent risk factor for PSA recurrence and cancer death in patients with prostate cancer.

KW - Disease progression

KW - Neoplasm invasiveness

KW - Prostate

KW - Prostatectomy

KW - Prostatic neoplasms

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