Lysine methylation of promoter-bound transcription factors and relevance to cancer

George R. Stark, Yuxin Wang, Tao Lu

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

p53, NFκB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFκB and STAT3 take place when they are bound to promoters, suggesting a more general model in which the binding of inducible transcription factors to DNA helps to recruit chromatin-modification machinery, which then may modify not only histones but also the bound transcription factors. Mutations of some histone-lysine methyltransferases and demethylases are linked to cancer, and these mutations may alter the methylation not only of histones but also of transcription factors, and thus may be tumorigenic through more than one mechanism.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalCell Research
Volume21
Issue number3
DOIs
StatePublished - Mar 2011
Externally publishedYes

Fingerprint

Methylation
Lysine
Transcription Factors
Histones
Neoplasms
Histone-Lysine N-Methyltransferase
Histone Demethylases
Mutation
Chromatin
DNA
Enzymes

Keywords

  • histones
  • Posttranslational modification
  • transcription factors

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Lysine methylation of promoter-bound transcription factors and relevance to cancer. / Stark, George R.; Wang, Yuxin; Lu, Tao.

In: Cell Research, Vol. 21, No. 3, 03.2011, p. 375-380.

Research output: Contribution to journalArticle

Stark, George R. ; Wang, Yuxin ; Lu, Tao. / Lysine methylation of promoter-bound transcription factors and relevance to cancer. In: Cell Research. 2011 ; Vol. 21, No. 3. pp. 375-380.
@article{4dcba187cd6e4895acd88bfa1e7cc6a2,
title = "Lysine methylation of promoter-bound transcription factors and relevance to cancer",
abstract = "p53, NFκB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFκB and STAT3 take place when they are bound to promoters, suggesting a more general model in which the binding of inducible transcription factors to DNA helps to recruit chromatin-modification machinery, which then may modify not only histones but also the bound transcription factors. Mutations of some histone-lysine methyltransferases and demethylases are linked to cancer, and these mutations may alter the methylation not only of histones but also of transcription factors, and thus may be tumorigenic through more than one mechanism.",
keywords = "histones, Posttranslational modification, transcription factors",
author = "Stark, {George R.} and Yuxin Wang and Tao Lu",
year = "2011",
month = "3",
doi = "10.1038/cr.2010.174",
language = "English (US)",
volume = "21",
pages = "375--380",
journal = "Cell Research",
issn = "1001-0602",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Lysine methylation of promoter-bound transcription factors and relevance to cancer

AU - Stark, George R.

AU - Wang, Yuxin

AU - Lu, Tao

PY - 2011/3

Y1 - 2011/3

N2 - p53, NFκB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFκB and STAT3 take place when they are bound to promoters, suggesting a more general model in which the binding of inducible transcription factors to DNA helps to recruit chromatin-modification machinery, which then may modify not only histones but also the bound transcription factors. Mutations of some histone-lysine methyltransferases and demethylases are linked to cancer, and these mutations may alter the methylation not only of histones but also of transcription factors, and thus may be tumorigenic through more than one mechanism.

AB - p53, NFκB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFκB and STAT3 take place when they are bound to promoters, suggesting a more general model in which the binding of inducible transcription factors to DNA helps to recruit chromatin-modification machinery, which then may modify not only histones but also the bound transcription factors. Mutations of some histone-lysine methyltransferases and demethylases are linked to cancer, and these mutations may alter the methylation not only of histones but also of transcription factors, and thus may be tumorigenic through more than one mechanism.

KW - histones

KW - Posttranslational modification

KW - transcription factors

UR - http://www.scopus.com/inward/record.url?scp=79952538100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952538100&partnerID=8YFLogxK

U2 - 10.1038/cr.2010.174

DO - 10.1038/cr.2010.174

M3 - Article

VL - 21

SP - 375

EP - 380

JO - Cell Research

JF - Cell Research

SN - 1001-0602

IS - 3

ER -