Lysophosphatidic acid aberrancies and hepatocellular carcinoma

Studies in the MDR2 gene knockout mouse

N. Skill, Jianmin Wu, Yan Xu, Zheng Zhao, Mary Maluccio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Studies show that lysophosphatidic acid (LPA) reprogramming is associated with the development of hepatocellular carcinoma (HCC). This manuscript evaluates the MDR2-/- model of HCC as a tool to examine the role of LPA reprogramming in the initiation/progression of HCC and identify novel treatment targets. Hepatic tumors developed in MDR2-/- mice between 9-12 m and serum LPA levels were greater in MDR2-/- when compared to controls. Blocking LPA biosynthesis/signaling significantly reduced tumor burden. LPA biosynthesis/signaling plays an important role in murine MDR2 -/- model and is potentially linked to regulation of TNFα or other cytokines that are relevant to high-risk patients.

Original languageEnglish
Pages (from-to)145-155
Number of pages11
JournalCancer Investigation
Volume31
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Gene Knockout Techniques
Knockout Mice
Hepatocellular Carcinoma
Tumor Burden
lysophosphatidic acid
Cytokines
Liver
Serum
Neoplasms

Keywords

  • CAMP
  • HCC
  • Multiple Drug Resistance Gene
  • TNF Alpha

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lysophosphatidic acid aberrancies and hepatocellular carcinoma : Studies in the MDR2 gene knockout mouse. / Skill, N.; Wu, Jianmin; Xu, Yan; Zhao, Zheng; Maluccio, Mary.

In: Cancer Investigation, Vol. 31, No. 2, 02.2013, p. 145-155.

Research output: Contribution to journalArticle

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