Studies show that lysophosphatidic acid (LPA) reprogramming is associated with the development of hepatocellular carcinoma (HCC). This manuscript evaluates the MDR2-/- model of HCC as a tool to examine the role of LPA reprogramming in the initiation/progression of HCC and identify novel treatment targets. Hepatic tumors developed in MDR2-/- mice between 9-12 m and serum LPA levels were greater in MDR2-/- when compared to controls. Blocking LPA biosynthesis/signaling significantly reduced tumor burden. LPA biosynthesis/signaling plays an important role in murine MDR2 -/- model and is potentially linked to regulation of TNFα or other cytokines that are relevant to high-risk patients.
- Multiple Drug Resistance Gene
- TNF Alpha
ASJC Scopus subject areas
- Cancer Research