Lysophosphatidylcholine as a ligand for immunoregulation

Janusz H.S. Kabarowski, Yan Xu, Owen N. Witte

Research output: Contribution to journalComment/debate

84 Scopus citations

Abstract

Despite the recognized effects of lysophosphatidylcholine upon cells of the immune system and its association with inflammatory processes, its mechanism of action has remained poorly characterized. Our recent identification of the first lysophosphatidylcholine receptor as an immunoregulatory G protein-coupled receptor named G2A whose genetic ablation results in the development of inflammatory autoimmune disease has, therefore, provided a new perspective on the role of this lysophospholipid as a modulator of immune responses. This commentary discusses the biological properties of lysophosphatidylcholine as an immunoregulatory ligand for cells of the innate and adaptive arms of the immune system. Although we focus primarily on ligand interactions with G2A, we also discuss the issue of possible functional redundancy with other receptors with recently established ligand specificities towards phosphorylcholine-containing lysolipids including lysophosphatidylcholine.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalBiochemical Pharmacology
Volume64
Issue number2
DOIs
StatePublished - Jul 15 2002

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Keywords

  • Immune regulation
  • Inflammation
  • Lysophosphatidylcholine
  • Oxidized low density lipoprotein
  • Phospholipase A
  • Systemic autoimmune disease

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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