Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A

J. H.S. Kabarowski, K. Zhu, L. Q. Le, O. N. Witte, Y. Xu

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258 Scopus citations

Abstract

Although the biological actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and systemic autoimmune disease are well recognized, LPC has not been linked to a specific cell-surface receptor. We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G protein-coupled receptor whose genetic ablation results in the development of autoimmunity. Activation of G2A by LPC increased intracellular calcium concentration, induced receptor internalization, activated ERK mitogen-activated protein kinase, and modified migratory responses of Jurkat T lymphocytes. This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis.

Original languageEnglish (US)
Pages (from-to)702-705
Number of pages4
JournalScience
Volume293
Issue number5530
DOIs
StatePublished - Jul 27 2001
Externally publishedYes

ASJC Scopus subject areas

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    Kabarowski, J. H. S., Zhu, K., Le, L. Q., Witte, O. N., & Xu, Y. (2001). Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. Science, 293(5530), 702-705. https://doi.org/10.1126/science.1061781