Lysophospholipid signaling in the epithelial ovarian cancer tumor microenvironment

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

As one of the important cancer hallmarks, metabolism reprogramming, including lipid metabolism alterations, occurs in tumor cells and the tumor microenvironment (TME). It plays an important role in tumorigenesis, progression, and metastasis. Lipids, and several lysophospholipids in particular, are elevated in the blood, ascites, and/or epithelial ovarian cancer (EOC) tissues, making them not only useful biomarkers, but also potential therapeutic targets. While the roles and signaling of these lipids in tumor cells are extensively studied, there is a significant gap in our understanding of their regulations and functions in the context of the microenvironment. This review focuses on the recent study development in several oncolipids, including lysophosphatidic acid and sphingosine-1-phosphate, with emphasis on TME in ovarian cancer.

Original languageEnglish (US)
Article number227
JournalCancers
Volume10
Issue number7
DOIs
StatePublished - Jul 9 2018

Fingerprint

Lysophospholipids
Tumor Microenvironment
Lipids
Cellular Microenvironment
Neoplasms
Lipid Metabolism
Ascites
Ovarian Neoplasms
Carcinogenesis
Biomarkers
Neoplasm Metastasis
Ovarian epithelial cancer
Therapeutics

Keywords

  • Epithelial ovarian cancer (EOC)
  • Lipids
  • Lysophosphatidic acid (LPA)
  • Lysophospholipids (LPLs)
  • Sphingosine-1-phosphate
  • Tumor microenvironment (TME)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lysophospholipid signaling in the epithelial ovarian cancer tumor microenvironment. / Xu, Yan.

In: Cancers, Vol. 10, No. 7, 227, 09.07.2018.

Research output: Contribution to journalReview article

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