Lysophospholipid signaling in the epithelial ovarian cancer tumor microenvironment

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

As one of the important cancer hallmarks, metabolism reprogramming, including lipid metabolism alterations, occurs in tumor cells and the tumor microenvironment (TME). It plays an important role in tumorigenesis, progression, and metastasis. Lipids, and several lysophospholipids in particular, are elevated in the blood, ascites, and/or epithelial ovarian cancer (EOC) tissues, making them not only useful biomarkers, but also potential therapeutic targets. While the roles and signaling of these lipids in tumor cells are extensively studied, there is a significant gap in our understanding of their regulations and functions in the context of the microenvironment. This review focuses on the recent study development in several oncolipids, including lysophosphatidic acid and sphingosine-1-phosphate, with emphasis on TME in ovarian cancer.

Original languageEnglish (US)
Article number227
JournalCancers
Volume10
Issue number7
DOIs
StatePublished - Jul 9 2018

Keywords

  • Epithelial ovarian cancer (EOC)
  • Lipids
  • Lysophosphatidic acid (LPA)
  • Lysophospholipids (LPLs)
  • Sphingosine-1-phosphate
  • Tumor microenvironment (TME)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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