Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung

Xuemei Lian, Cong Yan, Li Yang, Yan Xu, Hong Du

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The functional roles of neutral lipids are poorly understood in the lung. Blocking cholesteryl ester and triglyceride metabolism in lysosomal acid lipase gene knockout mice (lal-/-) resulted in a high level of neutrophil influx in the lungs as early as 2 mo of age. Bronchoalveolar macrophages appeared foamy and gradually increased in number with age progression. Affymetrix GeneChip array analysis of lung mRNA showed increased levels of proinflammatory cytokine (including IL-1β, IL-6, and TNF-α) and matrix metalloproteinase (including MMP-8, MMP-9, and MMP-12) expression in lal-/- mice. With age progression, some areas of lal-/- mice developed severe abnormal cell proliferation and alveolar remodeling. In other areas, alveolar destruction (i.e., emphysema) was observed. In addition, Clara cell hypertrophy and hyperplasia developed in conducting airways. The pathophysiological phenotypes in the lal-/- mouse lungs became more severe with increasing age. The studies support the concept that neutral lipid metabolites play essential roles in pulmonary homeostasis, inflammatory responses, remodeling, and injury repair.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume286
Issue number4 30-4
StatePublished - Apr 2004
Externally publishedYes

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Matrix Metalloproteinases
Inflammation
Lung
Sterol Esterase
Lipids
Gene Knockout Techniques
Cholesterol Esters
Emphysema
Interleukin-1
Knockout Mice
Hypertrophy
Hyperplasia
Interleukin-6
Triglycerides
Neutrophils
Homeostasis
Macrophages
Cell Proliferation
Lysosomal acid lipase deficiency
Cytokines

Keywords

  • Emphysema
  • Neutral lipid
  • Remodeling

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cell Biology
  • Physiology

Cite this

Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. / Lian, Xuemei; Yan, Cong; Yang, Li; Xu, Yan; Du, Hong.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 286, No. 4 30-4, 04.2004.

Research output: Contribution to journalArticle

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