Macular microcirculation in cystoid maculopathy of diabetic patients

Oliver Arend, Andreas Remky, Alon Harris, Bemd Bertram, Martin Reim, Sebastian Wolf

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background-In patients with diabetic macular oedema and central cysts ischaemia of the retina appears to be an important contributing factor in the pathogenesis of cysts. This study was performed to fiurther elucidate the role of the inner retinal microcirculation in diabetic cystoid macular oedema (CMO). Methods-Video fluorescein angiography allows visualisation of the macular microvasculature and measurements of the capillary blood velocity (CBV), foveal avascular zone (FAZ), and perifoveal intercapillary area (PIA, characterising capillary density). Results-Twenty three diabetic subjects with CMO, matched diabetic patients without macular oedema (n=23), and healthy subjects (n=23) were included. CBV, PIA, and FAZ did not differ significantly among diabetic groups regardless of presence of cystoid changes. CBV was significantly reduced (p<0.000l) and PIA was more than doubled in both diabetic groups (p<0.0001) when compared with healthy subjects. Furthermore, FAZ showed a nearly doubled size in diabetic patients without macular oedema (p<0.O1) and a less pronounced enlargement (by 29%/0) in diabetics with CMO (p<0.5). Conclusion-The results indicate that the retinal microcirculation in diabetic patients is markedly altered when compared with healthy subjects, regardless of CMO presence. In CMO patients the microcirculatory changes are similar to those ofdiabetic patients without macular oedema. Thus inner retinal perfusion does not contribute to tissue ischaemia leading to cystoid formations in diabetic maculopathy.

Original languageEnglish
Pages (from-to)628-632
Number of pages5
JournalBritish Journal of Ophthalmology
Volume79
Issue number7
DOIs
StatePublished - 1995

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Macular Edema
Microcirculation
Healthy Volunteers
Cysts
Ischemia
Fluorescein Angiography
Microvessels
Retina
Perfusion

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine
  • Ophthalmology

Cite this

Macular microcirculation in cystoid maculopathy of diabetic patients. / Arend, Oliver; Remky, Andreas; Harris, Alon; Bertram, Bemd; Reim, Martin; Wolf, Sebastian.

In: British Journal of Ophthalmology, Vol. 79, No. 7, 1995, p. 628-632.

Research output: Contribution to journalArticle

Arend, Oliver ; Remky, Andreas ; Harris, Alon ; Bertram, Bemd ; Reim, Martin ; Wolf, Sebastian. / Macular microcirculation in cystoid maculopathy of diabetic patients. In: British Journal of Ophthalmology. 1995 ; Vol. 79, No. 7. pp. 628-632.
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abstract = "Background-In patients with diabetic macular oedema and central cysts ischaemia of the retina appears to be an important contributing factor in the pathogenesis of cysts. This study was performed to fiurther elucidate the role of the inner retinal microcirculation in diabetic cystoid macular oedema (CMO). Methods-Video fluorescein angiography allows visualisation of the macular microvasculature and measurements of the capillary blood velocity (CBV), foveal avascular zone (FAZ), and perifoveal intercapillary area (PIA, characterising capillary density). Results-Twenty three diabetic subjects with CMO, matched diabetic patients without macular oedema (n=23), and healthy subjects (n=23) were included. CBV, PIA, and FAZ did not differ significantly among diabetic groups regardless of presence of cystoid changes. CBV was significantly reduced (p<0.000l) and PIA was more than doubled in both diabetic groups (p<0.0001) when compared with healthy subjects. Furthermore, FAZ showed a nearly doubled size in diabetic patients without macular oedema (p<0.O1) and a less pronounced enlargement (by 29{\%}/0) in diabetics with CMO (p<0.5). Conclusion-The results indicate that the retinal microcirculation in diabetic patients is markedly altered when compared with healthy subjects, regardless of CMO presence. In CMO patients the microcirculatory changes are similar to those ofdiabetic patients without macular oedema. Thus inner retinal perfusion does not contribute to tissue ischaemia leading to cystoid formations in diabetic maculopathy.",
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