Macular pigment and risk for age-related macular degeneration in subjects from a northern European population

S. Beatty, I. J. Murray, D. B. Henson, D. Carden, H. H. Koh, M. E. Boulton

Research output: Contribution to journalArticle

314 Citations (Scopus)

Abstract

Purpose. Age and advanced disease in the fellow eye are the two most important risk factors for age-related macular degeneration (AMD). In this study, the authors investigated the relationship between these variables and the optical density of macular pigment (MP) in a group of subjects from a northern European population. Methods. The optical density of MP was measured psychophysically in 46 subjects ranging in age from 21 to 81 years with healthy maculae and in 9 healthy eyes known to be at high-risk of AMD because of advanced disease in the fellow eye. Each eye in the latter group was matched with a control eye on the basis of variables believed to be associated with the optical density of MP (iris color, gender, smoking habits, age, and lens density). Results. There was an age-related decline in the optical density of macular pigment among volunteers with no ocular disease (right eye: r2 = 0.29, P = 0.0006; left eye: r2 = 0.29, P <0.0001). Healthy eyes predisposed to AMD had significantly less MP than healthy eyes at no such risk (Wilcoxon's signed rank test: P = 0.015). Conclusions. The two most important risk factors for AMD are associated with a relative absence of MP. These findings are consistent with the hypothesis that supplemental lutein and zeaxanthin may delay, avert, or modify the course of this disease.

Original languageEnglish (US)
Pages (from-to)439-446
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume42
Issue number2
StatePublished - 2001
Externally publishedYes

Fingerprint

Macular Degeneration
Population
Macular Pigment
Lutein
Eye Diseases
Iris
Nonparametric Statistics
Lenses
Habits
Volunteers
Research Design
Color
Smoking

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Beatty, S., Murray, I. J., Henson, D. B., Carden, D., Koh, H. H., & Boulton, M. E. (2001). Macular pigment and risk for age-related macular degeneration in subjects from a northern European population. Investigative Ophthalmology and Visual Science, 42(2), 439-446.

Macular pigment and risk for age-related macular degeneration in subjects from a northern European population. / Beatty, S.; Murray, I. J.; Henson, D. B.; Carden, D.; Koh, H. H.; Boulton, M. E.

In: Investigative Ophthalmology and Visual Science, Vol. 42, No. 2, 2001, p. 439-446.

Research output: Contribution to journalArticle

Beatty, S, Murray, IJ, Henson, DB, Carden, D, Koh, HH & Boulton, ME 2001, 'Macular pigment and risk for age-related macular degeneration in subjects from a northern European population', Investigative Ophthalmology and Visual Science, vol. 42, no. 2, pp. 439-446.
Beatty, S. ; Murray, I. J. ; Henson, D. B. ; Carden, D. ; Koh, H. H. ; Boulton, M. E. / Macular pigment and risk for age-related macular degeneration in subjects from a northern European population. In: Investigative Ophthalmology and Visual Science. 2001 ; Vol. 42, No. 2. pp. 439-446.
@article{14461c448ad54a4f909074ec032307c3,
title = "Macular pigment and risk for age-related macular degeneration in subjects from a northern European population",
abstract = "Purpose. Age and advanced disease in the fellow eye are the two most important risk factors for age-related macular degeneration (AMD). In this study, the authors investigated the relationship between these variables and the optical density of macular pigment (MP) in a group of subjects from a northern European population. Methods. The optical density of MP was measured psychophysically in 46 subjects ranging in age from 21 to 81 years with healthy maculae and in 9 healthy eyes known to be at high-risk of AMD because of advanced disease in the fellow eye. Each eye in the latter group was matched with a control eye on the basis of variables believed to be associated with the optical density of MP (iris color, gender, smoking habits, age, and lens density). Results. There was an age-related decline in the optical density of macular pigment among volunteers with no ocular disease (right eye: r2 = 0.29, P = 0.0006; left eye: r2 = 0.29, P <0.0001). Healthy eyes predisposed to AMD had significantly less MP than healthy eyes at no such risk (Wilcoxon's signed rank test: P = 0.015). Conclusions. The two most important risk factors for AMD are associated with a relative absence of MP. These findings are consistent with the hypothesis that supplemental lutein and zeaxanthin may delay, avert, or modify the course of this disease.",
author = "S. Beatty and Murray, {I. J.} and Henson, {D. B.} and D. Carden and Koh, {H. H.} and Boulton, {M. E.}",
year = "2001",
language = "English (US)",
volume = "42",
pages = "439--446",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "2",

}

TY - JOUR

T1 - Macular pigment and risk for age-related macular degeneration in subjects from a northern European population

AU - Beatty, S.

AU - Murray, I. J.

AU - Henson, D. B.

AU - Carden, D.

AU - Koh, H. H.

AU - Boulton, M. E.

PY - 2001

Y1 - 2001

N2 - Purpose. Age and advanced disease in the fellow eye are the two most important risk factors for age-related macular degeneration (AMD). In this study, the authors investigated the relationship between these variables and the optical density of macular pigment (MP) in a group of subjects from a northern European population. Methods. The optical density of MP was measured psychophysically in 46 subjects ranging in age from 21 to 81 years with healthy maculae and in 9 healthy eyes known to be at high-risk of AMD because of advanced disease in the fellow eye. Each eye in the latter group was matched with a control eye on the basis of variables believed to be associated with the optical density of MP (iris color, gender, smoking habits, age, and lens density). Results. There was an age-related decline in the optical density of macular pigment among volunteers with no ocular disease (right eye: r2 = 0.29, P = 0.0006; left eye: r2 = 0.29, P <0.0001). Healthy eyes predisposed to AMD had significantly less MP than healthy eyes at no such risk (Wilcoxon's signed rank test: P = 0.015). Conclusions. The two most important risk factors for AMD are associated with a relative absence of MP. These findings are consistent with the hypothesis that supplemental lutein and zeaxanthin may delay, avert, or modify the course of this disease.

AB - Purpose. Age and advanced disease in the fellow eye are the two most important risk factors for age-related macular degeneration (AMD). In this study, the authors investigated the relationship between these variables and the optical density of macular pigment (MP) in a group of subjects from a northern European population. Methods. The optical density of MP was measured psychophysically in 46 subjects ranging in age from 21 to 81 years with healthy maculae and in 9 healthy eyes known to be at high-risk of AMD because of advanced disease in the fellow eye. Each eye in the latter group was matched with a control eye on the basis of variables believed to be associated with the optical density of MP (iris color, gender, smoking habits, age, and lens density). Results. There was an age-related decline in the optical density of macular pigment among volunteers with no ocular disease (right eye: r2 = 0.29, P = 0.0006; left eye: r2 = 0.29, P <0.0001). Healthy eyes predisposed to AMD had significantly less MP than healthy eyes at no such risk (Wilcoxon's signed rank test: P = 0.015). Conclusions. The two most important risk factors for AMD are associated with a relative absence of MP. These findings are consistent with the hypothesis that supplemental lutein and zeaxanthin may delay, avert, or modify the course of this disease.

UR - http://www.scopus.com/inward/record.url?scp=0035142770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035142770&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 439

EP - 446

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 2

ER -