Macular structural characteristics in children with congenital and developmental cataracts

Jingyun Wang, Heather A. Smith, Dana L. Donaldson, Kathryn M. Haider, Gavin J. Roberts, Derek T. Sprunger, Daniel E. Neely, David A. Plager

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To investigate macular structural characteristics in children with congenital or developmental cataracts.

METHODS: Children 5-16 years of age with a history of surgery for congenital or acquired cataract were enrolled. Eligible patients had visual acuity of 20/400 or better and≤ge;37 weeks gestational age at birth. Patients were divided into two groups: unilateral (n = 22) and bilateral (n = 19). Fourier domain optical coherence tomography (FD-OCT) was used to image the retinal structure. Retinal volume scans centered on the fovea were obtained. Using the instrument's segmentation software, central subfield thickness (CST) and the thickness of the inner and outer retinal layer regions were measured.

RESULTS: In the unilateral group, 1 child with persistent fetal vasculature had unidentifiable retinal structure and was excluded. Most unilateral eyes (20/21) had a CST within the normal range. However, the CST, superior, nasal, inferior, and temporal sectors were all significantly thicker in the cataractous eye compared to the noncataractous eye (all P≤lt; 0.01 [paired t test]). The interocular difference for CST was not associated with age at surgery or interocular difference for visual acuity. In the bilateral group, although 34 of 38 eyes were within the normal range, the average CST of this group was significantly thicker than the noncataractous eye in the unilateral group.

CONCLUSIONS: Following cataract extraction during infancy or childhood, most cataractous eyes had normal macular structure. Cataractous eyes of both unilaterally and bilaterally affected children have thicker CST values compared to the noncataractous eye.

Original languageEnglish (US)
Pages (from-to)417-422
Number of pages6
JournalJournal of AAPOS
Volume18
Issue number5
DOIs
StatePublished - Oct 1 2014

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Cataract
Visual Acuity
Reference Values
Cataract Extraction
Optical Coherence Tomography
Nose
Gestational Age
Software
Parturition

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Cite this

Macular structural characteristics in children with congenital and developmental cataracts. / Wang, Jingyun; Smith, Heather A.; Donaldson, Dana L.; Haider, Kathryn M.; Roberts, Gavin J.; Sprunger, Derek T.; Neely, Daniel E.; Plager, David A.

In: Journal of AAPOS, Vol. 18, No. 5, 01.10.2014, p. 417-422.

Research output: Contribution to journalArticle

Wang, Jingyun ; Smith, Heather A. ; Donaldson, Dana L. ; Haider, Kathryn M. ; Roberts, Gavin J. ; Sprunger, Derek T. ; Neely, Daniel E. ; Plager, David A. / Macular structural characteristics in children with congenital and developmental cataracts. In: Journal of AAPOS. 2014 ; Vol. 18, No. 5. pp. 417-422.
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N2 - PURPOSE: To investigate macular structural characteristics in children with congenital or developmental cataracts.METHODS: Children 5-16 years of age with a history of surgery for congenital or acquired cataract were enrolled. Eligible patients had visual acuity of 20/400 or better and≤ge;37 weeks gestational age at birth. Patients were divided into two groups: unilateral (n = 22) and bilateral (n = 19). Fourier domain optical coherence tomography (FD-OCT) was used to image the retinal structure. Retinal volume scans centered on the fovea were obtained. Using the instrument's segmentation software, central subfield thickness (CST) and the thickness of the inner and outer retinal layer regions were measured.RESULTS: In the unilateral group, 1 child with persistent fetal vasculature had unidentifiable retinal structure and was excluded. Most unilateral eyes (20/21) had a CST within the normal range. However, the CST, superior, nasal, inferior, and temporal sectors were all significantly thicker in the cataractous eye compared to the noncataractous eye (all P≤lt; 0.01 [paired t test]). The interocular difference for CST was not associated with age at surgery or interocular difference for visual acuity. In the bilateral group, although 34 of 38 eyes were within the normal range, the average CST of this group was significantly thicker than the noncataractous eye in the unilateral group.CONCLUSIONS: Following cataract extraction during infancy or childhood, most cataractous eyes had normal macular structure. Cataractous eyes of both unilaterally and bilaterally affected children have thicker CST values compared to the noncataractous eye.

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