Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women

Yiqing Song, Paul M. Ridker, Jo Ann E. Manson, Nancy R. Cook, Julie E. Buring, Simin Liu

Research output: Contribution to journalArticle

196 Scopus citations


OBJECTIVE - The aim of this study was to examine whether and to what extent magnesium intake is related to systemic inflammation and the metabolic syndrome. RESEARCH DESIGN AND METHODS - We performed a cross-sectional analysis on data from 11,686 women ≥45 years of age participating in the Women's Health Study who were initially free of cardiovascular disease and cancer and had no use of postmenopausal hormones. RESULTS - In age- and BMI-adjusted analyses, magnesium intake was inversely associated with plasma C-reactive protein (CRP) concentrations; CRP concentrations were 12% lower in the highest intake quintile than in the lowest (P for trend <0.0001). This association was not appreciably altered by further adjustment for other potential confounding variables including dietary factors; the mean CRP concentrations for ascending quintiles of magnesium intake were 1.50, 1.39, 1.35, 1.34, and 1.31 mg/l (P for trend = 0.0003). This inverse association was stronger for women with a BMI ≥25 kg/m2 (P < 0.0001 for interaction) and those who were current or past smokers (P = 0.0009 for interaction). After adjustment for confounding lifestyle and dietary factors, women in the highest quintile of magnesium intake had 27% lower risk of the metabolic syndrome (defined according to the National Cholesterol Education Program criteria) compared with those in the lowest quintile of intake (odds ratio 0.73 [95% CI 0.60-0.88], P for trend = 0.0008). CONCLUSIONS - Our results suggest that magnesium intake is inversely associated with systemic inflammation and the prevalence of the metabolic syndrome in middle-aged and older women.

Original languageEnglish (US)
Pages (from-to)1438-1444
Number of pages7
JournalDiabetes care
Issue number6
StatePublished - Jun 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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