Magnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP)

a comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

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1 Citation (Scopus)

Abstract

Characteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T 1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T 1 -weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based on traditional ductal imaging alone. There is an urgent need to develop new diagnostic criteria that incorporate both parenchymal and ductal features of CP seen by MRI/MRCP. Designed to fulfill this clinical need, we present the MINIMAP study, which was funded in September 2018 by the National Institutes of Health. This is a comprehensive quantitative MR imaging study which will be performed at multiple institutions in well-phenotyped CP patient cohorts. We hypothesize that quantitative MRI/MRCP features can serve as valuable non-invasive imaging biomarkers to detect and grade CP. We will evaluate the role of T 1 relaxometry, ECV, T 1 -weighted gradient echo SIR, MRE, arteriovenous enhancement ratio, ADC, pancreas volume/atrophy, pancreatic fat fraction, ductal features, and pancreatic exocrine output following secretin stimulation in the assessment of CP. We will attempt to generate a multi-parametric pancreatic tissue fibrosis (PTF) scoring system. We anticipate that a quantitative scoring system may serve as a biomarker of pancreatic fibrosis; hence this imaging technique can be used in clinical practice as well as clinical trials to evaluate the efficacy of agents which may slow the progression or reverse measures of CP.

Original languageEnglish (US)
JournalAbdominal Radiology
DOIs
StatePublished - Jan 1 2019

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Chronic Pancreatitis
Pancreatic Neoplasms
Fibrosis
Magnetic Resonance Imaging
Elasticity Imaging Techniques
Biomarkers
Secretin
National Institutes of Health (U.S.)
Atrophy
Pancreas
Fats
Clinical Trials

Keywords

  • Chronic pancreatitis
  • Diffusion-weighted imaging
  • Extracellular volume
  • MR elastography
  • MRCP
  • MRI
  • T mapping

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

@article{dcf416ef873141d0808f4c0c447eb51e,
title = "Magnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP): a comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer",
abstract = "Characteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T 1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T 1 -weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based on traditional ductal imaging alone. There is an urgent need to develop new diagnostic criteria that incorporate both parenchymal and ductal features of CP seen by MRI/MRCP. Designed to fulfill this clinical need, we present the MINIMAP study, which was funded in September 2018 by the National Institutes of Health. This is a comprehensive quantitative MR imaging study which will be performed at multiple institutions in well-phenotyped CP patient cohorts. We hypothesize that quantitative MRI/MRCP features can serve as valuable non-invasive imaging biomarkers to detect and grade CP. We will evaluate the role of T 1 relaxometry, ECV, T 1 -weighted gradient echo SIR, MRE, arteriovenous enhancement ratio, ADC, pancreas volume/atrophy, pancreatic fat fraction, ductal features, and pancreatic exocrine output following secretin stimulation in the assessment of CP. We will attempt to generate a multi-parametric pancreatic tissue fibrosis (PTF) scoring system. We anticipate that a quantitative scoring system may serve as a biomarker of pancreatic fibrosis; hence this imaging technique can be used in clinical practice as well as clinical trials to evaluate the efficacy of agents which may slow the progression or reverse measures of CP.",
keywords = "Chronic pancreatitis, Diffusion-weighted imaging, Extracellular volume, MR elastography, MRCP, MRI, T mapping",
author = "{the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer} and Temel Tirkes and Dhiraj Yadav and Conwell, {Darwin L.} and Paul Territo and Xuandong Zhao and Venkatesh, {Sudhakar K.} and Arunark Kolipaka and Liang Li and Pisegna, {Joseph R.} and Pandol, {Stephen J.} and Park, {Walter G.} and Mark Topazian and Jose Serrano and Evan Fogel",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00261-019-02049-5",
language = "English (US)",
journal = "Abdominal Radiology",
issn = "2366-004X",
publisher = "Springer New York",

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T2 - a comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

AU - the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

AU - Tirkes, Temel

AU - Yadav, Dhiraj

AU - Conwell, Darwin L.

AU - Territo, Paul

AU - Zhao, Xuandong

AU - Venkatesh, Sudhakar K.

AU - Kolipaka, Arunark

AU - Li, Liang

AU - Pisegna, Joseph R.

AU - Pandol, Stephen J.

AU - Park, Walter G.

AU - Topazian, Mark

AU - Serrano, Jose

AU - Fogel, Evan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Characteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T 1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T 1 -weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based on traditional ductal imaging alone. There is an urgent need to develop new diagnostic criteria that incorporate both parenchymal and ductal features of CP seen by MRI/MRCP. Designed to fulfill this clinical need, we present the MINIMAP study, which was funded in September 2018 by the National Institutes of Health. This is a comprehensive quantitative MR imaging study which will be performed at multiple institutions in well-phenotyped CP patient cohorts. We hypothesize that quantitative MRI/MRCP features can serve as valuable non-invasive imaging biomarkers to detect and grade CP. We will evaluate the role of T 1 relaxometry, ECV, T 1 -weighted gradient echo SIR, MRE, arteriovenous enhancement ratio, ADC, pancreas volume/atrophy, pancreatic fat fraction, ductal features, and pancreatic exocrine output following secretin stimulation in the assessment of CP. We will attempt to generate a multi-parametric pancreatic tissue fibrosis (PTF) scoring system. We anticipate that a quantitative scoring system may serve as a biomarker of pancreatic fibrosis; hence this imaging technique can be used in clinical practice as well as clinical trials to evaluate the efficacy of agents which may slow the progression or reverse measures of CP.

AB - Characteristic features of chronic pancreatitis (CP) may be absent on standard imaging studies. Quantitative Magnetic Resonance Imaging (MRI) techniques such as T 1 mapping, extracellular volume (ECV) fraction, diffusion-weighted imaging (DWI) with apparent diffusion coefficient map (ADC), MR elastography (MRE), and T 1 -weighted signal intensity ratio (SIR) have shown promise for the diagnosis and grading severity of CP. However, radiologists still use the Cambridge classification which is based on traditional ductal imaging alone. There is an urgent need to develop new diagnostic criteria that incorporate both parenchymal and ductal features of CP seen by MRI/MRCP. Designed to fulfill this clinical need, we present the MINIMAP study, which was funded in September 2018 by the National Institutes of Health. This is a comprehensive quantitative MR imaging study which will be performed at multiple institutions in well-phenotyped CP patient cohorts. We hypothesize that quantitative MRI/MRCP features can serve as valuable non-invasive imaging biomarkers to detect and grade CP. We will evaluate the role of T 1 relaxometry, ECV, T 1 -weighted gradient echo SIR, MRE, arteriovenous enhancement ratio, ADC, pancreas volume/atrophy, pancreatic fat fraction, ductal features, and pancreatic exocrine output following secretin stimulation in the assessment of CP. We will attempt to generate a multi-parametric pancreatic tissue fibrosis (PTF) scoring system. We anticipate that a quantitative scoring system may serve as a biomarker of pancreatic fibrosis; hence this imaging technique can be used in clinical practice as well as clinical trials to evaluate the efficacy of agents which may slow the progression or reverse measures of CP.

KW - Chronic pancreatitis

KW - Diffusion-weighted imaging

KW - Extracellular volume

KW - MR elastography

KW - MRCP

KW - MRI

KW - T mapping

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JO - Abdominal Radiology

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SN - 2366-004X

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