Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects

David C. Steffens, William M. McDonald, Larry A. Tupler, Orest Boyko, K. Ranga Rama Krishnan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

To study patterns of iron deposition in the putamen in aging, we reviewed brain magnetic resonance imaging (MRI) scans of 56 normal subjects. We developed the Signal Hypointensity in the Putamen (SHIP) Scale, a semiquantitative measure, to evaluate putamen nuclei for extent of iron deposition relative to the globus pallidus. The SHIP score was highly reliable (κ = 0.76) and significantly correlated with age (P < 0.0001). We found that age-related iron deposition in putamen nuclei follows a characteristic pattern along a posterolateral-to-anteromedial gradient. This gradient may be related to the microvasculature of the putamen. Other studies are needed to replicate our findings in patients with affective and other neuropsychiatric disorders and to clarify the pathophysiological mechanisms that govern these changes.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalPsychiatry Research - Neuroimaging
Volume68
Issue number1
DOIs
StatePublished - Nov 25 1996
Externally publishedYes

Fingerprint

Putamen
Normal Distribution
Iron
Magnetic Resonance Imaging
Globus Pallidus
Microvessels
Brain

Keywords

  • aging
  • basal ganglia
  • globus pallidus

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects. / Steffens, David C.; McDonald, William M.; Tupler, Larry A.; Boyko, Orest; Krishnan, K. Ranga Rama.

In: Psychiatry Research - Neuroimaging, Vol. 68, No. 1, 25.11.1996, p. 55-61.

Research output: Contribution to journalArticle

Steffens, David C. ; McDonald, William M. ; Tupler, Larry A. ; Boyko, Orest ; Krishnan, K. Ranga Rama. / Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects. In: Psychiatry Research - Neuroimaging. 1996 ; Vol. 68, No. 1. pp. 55-61.
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