Magnetic Resonance Imaging Findings in Children With a First Recognized Seizure

Andrew J. Kalnin, Philip S. Fastenau, Ton J. deGrauw, Beverly S. Musick, Susan Perkins, Cynthia S. Johnson, Vincent Mathews, John C. Egelhoff, David Dunn, Joan K. Austin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This study characterized structural abnormalities associated with onset of seizures in children, using magnetic resonance imaging and a standardized classification system in a large prospective cohort. Two hundred eighty-one children aged 6-14 years completed magnetic resonance imaging within 6 months of their first recognized seizure. Most examinations were performed with a standardized, dedicated seizure protocol; all were scored using a standard scoring system. At least one magnetic resonance imaging abnormality was identified in 87 of 281 (31%) children with a first recognized seizure. Two or more abnormalities were identified in 34 (12%). The commonest abnormalities were ventricular enlargement (51%), leukomalacia/gliosis (23%), gray-matter lesions such as heterotopias and cortical dysplasia (12%), volume loss (12%), other white-matter lesions (9%), and encephalomalacia (6%). Abnormalities defined as significant, or potentially related to seizures, occurred in 40 (14%). Temporal lobe and hippocampal abnormalities were detected at a higher frequency than in previous studies (13/87). Magnetic resonance imaging and a standardized, reliable, valid scoring system demonstrated a higher rate of abnormal findings than previously reported, including findings formerly considered incidental. Practice parameters may need revision, to expand the definition of significant abnormalities and support wider use of magnetic resonance imaging in children with newly diagnosed seizures.

Original languageEnglish
Pages (from-to)404-414
Number of pages11
JournalPediatric Neurology
Volume39
Issue number6
DOIs
StatePublished - Dec 2008

Fingerprint

Seizures
Magnetic Resonance Imaging
Encephalomalacia
Malformations of Cortical Development
Gliosis
Temporal Lobe

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Kalnin, A. J., Fastenau, P. S., deGrauw, T. J., Musick, B. S., Perkins, S., Johnson, C. S., ... Austin, J. K. (2008). Magnetic Resonance Imaging Findings in Children With a First Recognized Seizure. Pediatric Neurology, 39(6), 404-414. https://doi.org/10.1016/j.pediatrneurol.2008.08.008

Magnetic Resonance Imaging Findings in Children With a First Recognized Seizure. / Kalnin, Andrew J.; Fastenau, Philip S.; deGrauw, Ton J.; Musick, Beverly S.; Perkins, Susan; Johnson, Cynthia S.; Mathews, Vincent; Egelhoff, John C.; Dunn, David; Austin, Joan K.

In: Pediatric Neurology, Vol. 39, No. 6, 12.2008, p. 404-414.

Research output: Contribution to journalArticle

Kalnin, AJ, Fastenau, PS, deGrauw, TJ, Musick, BS, Perkins, S, Johnson, CS, Mathews, V, Egelhoff, JC, Dunn, D & Austin, JK 2008, 'Magnetic Resonance Imaging Findings in Children With a First Recognized Seizure', Pediatric Neurology, vol. 39, no. 6, pp. 404-414. https://doi.org/10.1016/j.pediatrneurol.2008.08.008
Kalnin, Andrew J. ; Fastenau, Philip S. ; deGrauw, Ton J. ; Musick, Beverly S. ; Perkins, Susan ; Johnson, Cynthia S. ; Mathews, Vincent ; Egelhoff, John C. ; Dunn, David ; Austin, Joan K. / Magnetic Resonance Imaging Findings in Children With a First Recognized Seizure. In: Pediatric Neurology. 2008 ; Vol. 39, No. 6. pp. 404-414.
@article{5cd388ccae88457eb7b0e37d115f851f,
title = "Magnetic Resonance Imaging Findings in Children With a First Recognized Seizure",
abstract = "This study characterized structural abnormalities associated with onset of seizures in children, using magnetic resonance imaging and a standardized classification system in a large prospective cohort. Two hundred eighty-one children aged 6-14 years completed magnetic resonance imaging within 6 months of their first recognized seizure. Most examinations were performed with a standardized, dedicated seizure protocol; all were scored using a standard scoring system. At least one magnetic resonance imaging abnormality was identified in 87 of 281 (31{\%}) children with a first recognized seizure. Two or more abnormalities were identified in 34 (12{\%}). The commonest abnormalities were ventricular enlargement (51{\%}), leukomalacia/gliosis (23{\%}), gray-matter lesions such as heterotopias and cortical dysplasia (12{\%}), volume loss (12{\%}), other white-matter lesions (9{\%}), and encephalomalacia (6{\%}). Abnormalities defined as significant, or potentially related to seizures, occurred in 40 (14{\%}). Temporal lobe and hippocampal abnormalities were detected at a higher frequency than in previous studies (13/87). Magnetic resonance imaging and a standardized, reliable, valid scoring system demonstrated a higher rate of abnormal findings than previously reported, including findings formerly considered incidental. Practice parameters may need revision, to expand the definition of significant abnormalities and support wider use of magnetic resonance imaging in children with newly diagnosed seizures.",
author = "Kalnin, {Andrew J.} and Fastenau, {Philip S.} and deGrauw, {Ton J.} and Musick, {Beverly S.} and Susan Perkins and Johnson, {Cynthia S.} and Vincent Mathews and Egelhoff, {John C.} and David Dunn and Austin, {Joan K.}",
year = "2008",
month = "12",
doi = "10.1016/j.pediatrneurol.2008.08.008",
language = "English",
volume = "39",
pages = "404--414",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Magnetic Resonance Imaging Findings in Children With a First Recognized Seizure

AU - Kalnin, Andrew J.

AU - Fastenau, Philip S.

AU - deGrauw, Ton J.

AU - Musick, Beverly S.

AU - Perkins, Susan

AU - Johnson, Cynthia S.

AU - Mathews, Vincent

AU - Egelhoff, John C.

AU - Dunn, David

AU - Austin, Joan K.

PY - 2008/12

Y1 - 2008/12

N2 - This study characterized structural abnormalities associated with onset of seizures in children, using magnetic resonance imaging and a standardized classification system in a large prospective cohort. Two hundred eighty-one children aged 6-14 years completed magnetic resonance imaging within 6 months of their first recognized seizure. Most examinations were performed with a standardized, dedicated seizure protocol; all were scored using a standard scoring system. At least one magnetic resonance imaging abnormality was identified in 87 of 281 (31%) children with a first recognized seizure. Two or more abnormalities were identified in 34 (12%). The commonest abnormalities were ventricular enlargement (51%), leukomalacia/gliosis (23%), gray-matter lesions such as heterotopias and cortical dysplasia (12%), volume loss (12%), other white-matter lesions (9%), and encephalomalacia (6%). Abnormalities defined as significant, or potentially related to seizures, occurred in 40 (14%). Temporal lobe and hippocampal abnormalities were detected at a higher frequency than in previous studies (13/87). Magnetic resonance imaging and a standardized, reliable, valid scoring system demonstrated a higher rate of abnormal findings than previously reported, including findings formerly considered incidental. Practice parameters may need revision, to expand the definition of significant abnormalities and support wider use of magnetic resonance imaging in children with newly diagnosed seizures.

AB - This study characterized structural abnormalities associated with onset of seizures in children, using magnetic resonance imaging and a standardized classification system in a large prospective cohort. Two hundred eighty-one children aged 6-14 years completed magnetic resonance imaging within 6 months of their first recognized seizure. Most examinations were performed with a standardized, dedicated seizure protocol; all were scored using a standard scoring system. At least one magnetic resonance imaging abnormality was identified in 87 of 281 (31%) children with a first recognized seizure. Two or more abnormalities were identified in 34 (12%). The commonest abnormalities were ventricular enlargement (51%), leukomalacia/gliosis (23%), gray-matter lesions such as heterotopias and cortical dysplasia (12%), volume loss (12%), other white-matter lesions (9%), and encephalomalacia (6%). Abnormalities defined as significant, or potentially related to seizures, occurred in 40 (14%). Temporal lobe and hippocampal abnormalities were detected at a higher frequency than in previous studies (13/87). Magnetic resonance imaging and a standardized, reliable, valid scoring system demonstrated a higher rate of abnormal findings than previously reported, including findings formerly considered incidental. Practice parameters may need revision, to expand the definition of significant abnormalities and support wider use of magnetic resonance imaging in children with newly diagnosed seizures.

UR - http://www.scopus.com/inward/record.url?scp=56349119925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56349119925&partnerID=8YFLogxK

U2 - 10.1016/j.pediatrneurol.2008.08.008

DO - 10.1016/j.pediatrneurol.2008.08.008

M3 - Article

C2 - 19027586

AN - SCOPUS:56349119925

VL - 39

SP - 404

EP - 414

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

IS - 6

ER -