Magnetic Resonance Imaging of the Caudate Nuclei in Depression: Preliminary Observations

K. Ranga Rama Krishnan, William M. McDonald, P. Rodrigo Escalona, P. Murali Doraiswamy, Chul Na, Mustafa M. Husain, Gary S. Figiel, Orest Boyko, Everett H. Ellinwood, Charles B. Nemeroff

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

A role of the caudate nucleus in depression has been suggested from relevant clinical conditions, such as patients with Huntington's disease or caudate infarcts, as well as animal studies. Correlations of caudate nucleus disease with depressive symptoms have been limited to autopsy studies and cases of gross pathological disorder, such as large infarcts. We used serial axial high-field magnetic resonance images and an unbiased stereological technique to estimate the volumes of the caudate nuclei in 50 patients who met DSM-III criteria for major depression (23 men, 48.3±17 years old) in comparison with 50 age- and gender-matched normal controls free of major neurological and psychiatric disorders. Depressed patients had smaller caudate nucleus volumes (5.2±1.6 cm3) compared with controls (6.2±1.7 cm3). Right and left caudate nucleus volumes were smaller in depressed patients compared with controls. Age was negatively correlated with caudate nucleus volumes in depressed patients as well as in controls. Caudate nucleus volumes in depressed patients were inversely correlated with the bicaudate and bifrontal indices. These results may be the first demonstration of diminished caudate nucleus volumes in depression and suggest a role for the caudate nucleus in the pathogenesis of major depression.

Original languageEnglish (US)
Pages (from-to)553-557
Number of pages5
JournalArchives of General Psychiatry
Volume49
Issue number7
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Caudate Nucleus
Magnetic Resonance Imaging
Depression
Nucleus
Huntington Disease
Nervous System Diseases
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Autopsy
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Krishnan, K. R. R., McDonald, W. M., Escalona, P. R., Doraiswamy, P. M., Na, C., Husain, M. M., ... Nemeroff, C. B. (1992). Magnetic Resonance Imaging of the Caudate Nuclei in Depression: Preliminary Observations. Archives of General Psychiatry, 49(7), 553-557. https://doi.org/10.1001/archpsyc.1992.01820070047007

Magnetic Resonance Imaging of the Caudate Nuclei in Depression : Preliminary Observations. / Krishnan, K. Ranga Rama; McDonald, William M.; Escalona, P. Rodrigo; Doraiswamy, P. Murali; Na, Chul; Husain, Mustafa M.; Figiel, Gary S.; Boyko, Orest; Ellinwood, Everett H.; Nemeroff, Charles B.

In: Archives of General Psychiatry, Vol. 49, No. 7, 1992, p. 553-557.

Research output: Contribution to journalArticle

Krishnan, KRR, McDonald, WM, Escalona, PR, Doraiswamy, PM, Na, C, Husain, MM, Figiel, GS, Boyko, O, Ellinwood, EH & Nemeroff, CB 1992, 'Magnetic Resonance Imaging of the Caudate Nuclei in Depression: Preliminary Observations', Archives of General Psychiatry, vol. 49, no. 7, pp. 553-557. https://doi.org/10.1001/archpsyc.1992.01820070047007
Krishnan, K. Ranga Rama ; McDonald, William M. ; Escalona, P. Rodrigo ; Doraiswamy, P. Murali ; Na, Chul ; Husain, Mustafa M. ; Figiel, Gary S. ; Boyko, Orest ; Ellinwood, Everett H. ; Nemeroff, Charles B. / Magnetic Resonance Imaging of the Caudate Nuclei in Depression : Preliminary Observations. In: Archives of General Psychiatry. 1992 ; Vol. 49, No. 7. pp. 553-557.
@article{2876c9de543140319b18036053598031,
title = "Magnetic Resonance Imaging of the Caudate Nuclei in Depression: Preliminary Observations",
abstract = "A role of the caudate nucleus in depression has been suggested from relevant clinical conditions, such as patients with Huntington's disease or caudate infarcts, as well as animal studies. Correlations of caudate nucleus disease with depressive symptoms have been limited to autopsy studies and cases of gross pathological disorder, such as large infarcts. We used serial axial high-field magnetic resonance images and an unbiased stereological technique to estimate the volumes of the caudate nuclei in 50 patients who met DSM-III criteria for major depression (23 men, 48.3±17 years old) in comparison with 50 age- and gender-matched normal controls free of major neurological and psychiatric disorders. Depressed patients had smaller caudate nucleus volumes (5.2±1.6 cm3) compared with controls (6.2±1.7 cm3). Right and left caudate nucleus volumes were smaller in depressed patients compared with controls. Age was negatively correlated with caudate nucleus volumes in depressed patients as well as in controls. Caudate nucleus volumes in depressed patients were inversely correlated with the bicaudate and bifrontal indices. These results may be the first demonstration of diminished caudate nucleus volumes in depression and suggest a role for the caudate nucleus in the pathogenesis of major depression.",
author = "Krishnan, {K. Ranga Rama} and McDonald, {William M.} and Escalona, {P. Rodrigo} and Doraiswamy, {P. Murali} and Chul Na and Husain, {Mustafa M.} and Figiel, {Gary S.} and Orest Boyko and Ellinwood, {Everett H.} and Nemeroff, {Charles B.}",
year = "1992",
doi = "10.1001/archpsyc.1992.01820070047007",
language = "English (US)",
volume = "49",
pages = "553--557",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Magnetic Resonance Imaging of the Caudate Nuclei in Depression

T2 - Preliminary Observations

AU - Krishnan, K. Ranga Rama

AU - McDonald, William M.

AU - Escalona, P. Rodrigo

AU - Doraiswamy, P. Murali

AU - Na, Chul

AU - Husain, Mustafa M.

AU - Figiel, Gary S.

AU - Boyko, Orest

AU - Ellinwood, Everett H.

AU - Nemeroff, Charles B.

PY - 1992

Y1 - 1992

N2 - A role of the caudate nucleus in depression has been suggested from relevant clinical conditions, such as patients with Huntington's disease or caudate infarcts, as well as animal studies. Correlations of caudate nucleus disease with depressive symptoms have been limited to autopsy studies and cases of gross pathological disorder, such as large infarcts. We used serial axial high-field magnetic resonance images and an unbiased stereological technique to estimate the volumes of the caudate nuclei in 50 patients who met DSM-III criteria for major depression (23 men, 48.3±17 years old) in comparison with 50 age- and gender-matched normal controls free of major neurological and psychiatric disorders. Depressed patients had smaller caudate nucleus volumes (5.2±1.6 cm3) compared with controls (6.2±1.7 cm3). Right and left caudate nucleus volumes were smaller in depressed patients compared with controls. Age was negatively correlated with caudate nucleus volumes in depressed patients as well as in controls. Caudate nucleus volumes in depressed patients were inversely correlated with the bicaudate and bifrontal indices. These results may be the first demonstration of diminished caudate nucleus volumes in depression and suggest a role for the caudate nucleus in the pathogenesis of major depression.

AB - A role of the caudate nucleus in depression has been suggested from relevant clinical conditions, such as patients with Huntington's disease or caudate infarcts, as well as animal studies. Correlations of caudate nucleus disease with depressive symptoms have been limited to autopsy studies and cases of gross pathological disorder, such as large infarcts. We used serial axial high-field magnetic resonance images and an unbiased stereological technique to estimate the volumes of the caudate nuclei in 50 patients who met DSM-III criteria for major depression (23 men, 48.3±17 years old) in comparison with 50 age- and gender-matched normal controls free of major neurological and psychiatric disorders. Depressed patients had smaller caudate nucleus volumes (5.2±1.6 cm3) compared with controls (6.2±1.7 cm3). Right and left caudate nucleus volumes were smaller in depressed patients compared with controls. Age was negatively correlated with caudate nucleus volumes in depressed patients as well as in controls. Caudate nucleus volumes in depressed patients were inversely correlated with the bicaudate and bifrontal indices. These results may be the first demonstration of diminished caudate nucleus volumes in depression and suggest a role for the caudate nucleus in the pathogenesis of major depression.

UR - http://www.scopus.com/inward/record.url?scp=0026780268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026780268&partnerID=8YFLogxK

U2 - 10.1001/archpsyc.1992.01820070047007

DO - 10.1001/archpsyc.1992.01820070047007

M3 - Article

C2 - 1627046

AN - SCOPUS:0026780268

VL - 49

SP - 553

EP - 557

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 7

ER -