Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsy

Bassam A. Assaf, Kameel M. Karkar, Kenneth D. Laxer, Paul A. Garcia, Everett J. Austin, Nicholas Barbaro, Michael J. Aminoff

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Objective: We prospectively investigated the role of magnetoencephalography (MEG) in localizing the seizure focus and in predicting outcome to surgical resections for intractable temporal lobe epilepsy (TLE). Methods: We performed simultaneous interictal EEG and MEG recording (two 37-channel system) in 26 TLE patients followed by MEG source localization. We correlated early modeling dipoles with intracranial EEG, temporal surgical resection and surgical outcome. Results: There were 12 patients who had anterior temporal horizontal or tangential dipoles to the anterior infero-lateral temporal tip cortex. Two patients underwent selective amygdalo-hippocampectomy (SAH) and nine patients had antero-medial temporal lobectomy (AMTL). All patients had successful outcome except for one patient who initially failed SAH, but became seizure-free after AMTL. There were 11 patients who demonstrated anterior temporal vertical or tangential oblique dipoles. Five patients had AMTL and three had SAH; all became seizure free. Five of above 23 patients had invasive EEG and demonstrated mesial seizure onset. Three TLE patients had lateral vertical dipoles that were concordant with intracranial EEG and these became seizure free after temporal neocortical resections. Conclusions: MEG source analysis produces distinct source patterns that provide useful localizing information, predict surgical outcome, and may aid in planning limited surgical resection in TLE.

Original languageEnglish (US)
Pages (from-to)2066-2076
Number of pages11
JournalClinical Neurophysiology
Volume115
Issue number9
DOIs
StatePublished - Sep 2004
Externally publishedYes

Fingerprint

Magnetoencephalography
Temporal Lobe Epilepsy
Seizures
Electroencephalography
Temporal Lobe

Keywords

  • Dipole
  • EEG
  • Epilepsy
  • MEG
  • Outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Assaf, B. A., Karkar, K. M., Laxer, K. D., Garcia, P. A., Austin, E. J., Barbaro, N., & Aminoff, M. J. (2004). Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsy. Clinical Neurophysiology, 115(9), 2066-2076. https://doi.org/10.1016/j.clinph.2004.04.020

Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsy. / Assaf, Bassam A.; Karkar, Kameel M.; Laxer, Kenneth D.; Garcia, Paul A.; Austin, Everett J.; Barbaro, Nicholas; Aminoff, Michael J.

In: Clinical Neurophysiology, Vol. 115, No. 9, 09.2004, p. 2066-2076.

Research output: Contribution to journalArticle

Assaf, BA, Karkar, KM, Laxer, KD, Garcia, PA, Austin, EJ, Barbaro, N & Aminoff, MJ 2004, 'Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsy', Clinical Neurophysiology, vol. 115, no. 9, pp. 2066-2076. https://doi.org/10.1016/j.clinph.2004.04.020
Assaf, Bassam A. ; Karkar, Kameel M. ; Laxer, Kenneth D. ; Garcia, Paul A. ; Austin, Everett J. ; Barbaro, Nicholas ; Aminoff, Michael J. / Magnetoencephalography source localization and surgical outcome in temporal lobe epilepsy. In: Clinical Neurophysiology. 2004 ; Vol. 115, No. 9. pp. 2066-2076.
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