Le grade principal du score 7 de Gleason de la pièce opératoire corrélé à la progression biologique des patients traités par prostatectomie totale.

Translated title of the contribution: Main grade of Gleason's 7 score of the surgical sample correlated with biologic progression in patients treated for total prostatectomy

Rabi Tiguert, Vincent Ravery, David J. Grignon, Wael Sakr, David P. Wood, J. Edson Pontes

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

OBJECTIVES: To analyse the influence of the main grade of Gleason score 7 of the operative specimen correlated with the blood PSA level on the laboratory progression-free survival of patients treated by radical prostatectomy. MATERIALS AND METHODS: 331 patients consecutively treated by radical prostatectomy and presenting a Gleason score 7 were analysed. Exclusion criteria were the use of radiotherapy and/or preoperative and/or postoperative endocrine therapy. The main grade (3 or 4), histological stage, and blood PSA level were analysed for their predictive value of laboratory progression-free survival. The mean follow-up was 3.5 years (range: 13.6 to 72.8 months). Laboratory recurrence was defined by a PSA > 0.4 ng/ml. RESULTS: The main grade of Gleason score 7 was 3 in 199 (60%) patients and 4 in 132 (40%) patients with a mean follow-up of 3.6 years. Laboratory progression-free survival rates were 89% and 72% for main grades 3 and 4, respectively (p = 0.03). When the cancer was confined to the prostate, the progression-free survival rates were 96% and 88% for main grades 3 and 4, respectively (p = 0.01). For a PSA < 10 ng/ml, main grade 3 was associated with a better laboratory progression-free survival rate than main grade 4 (p = 0.0007). No difference in terms of laboratory progression was observed in the presence of extraprostatic extension or PSA > 10 ng/ml. CONCLUSION: A high correlation was observed between the main grade of Gleason score 7 and laboratory progression-free survival. Main grade 3 constituted a factor of better prognosis than main grade 4.

Translated title of the contributionMain grade of Gleason's 7 score of the surgical sample correlated with biologic progression in patients treated for total prostatectomy
Original languageFrench
Pages (from-to)31-36
Number of pages6
JournalProgrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
Volume12
Issue number1
StatePublished - Feb 2002

ASJC Scopus subject areas

  • Urology

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