Maintenance of a functional higher order chromatin structure: The role of the nuclear matrix in normal and disease states

Amelia K. Linnemann, Stephen A. Krawetz

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

The ordered packaging of DNA within the nucleus of somatic cells reflects a dynamic supportive structure that facilitates stable transcription interrupted by intermittent cycles of extreme condensation. This dynamic mode of packing and unpacking chromatin is intimately linked to the ability of the genome to specifically complex with both histones and non-histone proteins. Understanding the underlying mechanism that governs the formation of higher order chromatin structures is a key to understanding how local architecture modulates transcription. In part, the formation of these structures appears to be regulated through genomic looping that is dynamically mediated by attachment to the nuclear scaffold/matrix at S/MARs, i.e., Scaffold/Matrix Attachment Regions. Although the mechanism guiding the formation and use of these higher-ordered structures remains unknown, S/MARs continue to reveal a multitude of roles in development and the pathogenesis of disease.

Original languageEnglish (US)
Pages (from-to)231-243
Number of pages13
JournalGene Therapy and Molecular Biology
Volume13
Issue number1
StatePublished - 2009

Keywords

  • Disease
  • Gene regulation
  • LIS
  • Model
  • NaCl
  • Nuclear matrix
  • S/MAR attachment
  • Scaffold

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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