Maintenance of serum calcium by parathyroid hormone-related peptide during lactation in a hypoparathyroid patient

Kieren Mather, C. L. Chik, B. Corenblum

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We describe the changes in calcium homeostasis seen in a hypoparathyroid woman during the third trimester and with lactation following her second pregnancy. During lactation her need for supplemental calcium and calcitriol abated, and in fact she was transiently hypercalcemic and hypophosphatemic. This change was associated with a rise of serum parathyroid hormone-related peptide (PTHrP) released systemically during lactation. This is the first documentation of the time course of serum PTHrP levels from the late third trimester throughout lactation in a hypoparathyroid woman. In this context PTHrP may have sufficient biological activity to compensate for parathyroid hormone deficiency.

Original languageEnglish (US)
Pages (from-to)424-427
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume84
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Parathyroid Hormone-Related Protein
Lactation
Maintenance
Calcium
Third Pregnancy Trimester
Serum
Calcitriol
Bioactivity
Parathyroid Hormone
Documentation
Homeostasis
Pregnancy

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Maintenance of serum calcium by parathyroid hormone-related peptide during lactation in a hypoparathyroid patient. / Mather, Kieren; Chik, C. L.; Corenblum, B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 84, No. 2, 1999, p. 424-427.

Research output: Contribution to journalArticle

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