Major pathways of the reno-cardiovascular link: The sympathetic and renin-angiotensin systems

Peter J. Blankestijn, Gerard London, Danilo Fliser, Kitty J. Jager, Bengt Lindholm, David Goldsmith, Andrzej Wiecek, Gultekin Suleymanlar, Rajiv Agarwal, Alberto Ortiz, Ziad Massy, Alberto Martinez-Castelao, Adrian Covic, Friedo W. Dekker, Carmine Zoccali

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Chronic kidney disease is often characterized by enhanced activity of the renin-angiotensin system (RAS) and the sympathetic nervous system. Independent of their effect on blood pressure, these systems also contribute to the pathogenesis of both structural and functional cardiovascular abnormalities and contribute importantly to clinical outcome. There is much evidence that the diseased kidneys are of central importance in the pathogenesis of both abnormalities. Inhibitors of the RAS also reduce sympathetic overactivity. Future research should be aimed at addressing the pathophysiological mechanisms causing the enhanced activities. Given the fact that even a small kidney lesion can cause enhanced activity of the RAS and the sympathetic nervous system, it is likely that these pathophysiological mechanisms are operational in more disease conditions, including essential hypertension, heart failure, and obesity/metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalKidney International Supplements
Volume1
Issue number1
DOIs
StatePublished - Jun 1 2011

Keywords

  • chronic kidney disease
  • hypertension
  • renin angiotensin
  • sympathetic activity

ASJC Scopus subject areas

  • Nephrology

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    Blankestijn, P. J., London, G., Fliser, D., Jager, K. J., Lindholm, B., Goldsmith, D., Wiecek, A., Suleymanlar, G., Agarwal, R., Ortiz, A., Massy, Z., Martinez-Castelao, A., Covic, A., Dekker, F. W., & Zoccali, C. (2011). Major pathways of the reno-cardiovascular link: The sympathetic and renin-angiotensin systems. Kidney International Supplements, 1(1), 13-16. https://doi.org/10.1038/kisup.2011.3