Malabsorptive disorders of childhood

Rana F. Ammoury, Joseph Croffie

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

• Food is chemically reduced to digestive end products, made small enough to participate in the absorption process by various enzymes, and then transported across the intestinal epithelium by active transport, passive transport, facilitated diffusion, or endocytosis. Disruption of any of these physiologic stages may lead to maldigestion, malabsorption, or both. • Based on strong research evidence, the most common type of carbohydrate malabsorption is lactose malabsorption due to "adult-onset" lactase deficiency. (1) • Protein malabsorption leading to failure to thrive, hypoproteinemia, and edema occurs in pancreatic insufficiency, enterocyte deficiency, and impaired amino acid or peptide transport by the enterocyte. • Fat malabsorption occurs in pancreatic insufficiency, which can be congenital in conditions such as cystic fibrosis and Shwachman-Diamond syndrome, or acquired, as in chronic pancreatitis. Fat malabsorption also is seen in diseases that impair bile production or excretion and in abetalipoproteinemia. • A detailed history and physical examination and judicious use of laboratory studies usually provide the information necessary to diagnose a maldigestive or malabsorptive disorder. • Management aims at enabling patients to grow and develop normally.

Original languageEnglish
Pages (from-to)407-416
Number of pages10
JournalPediatrics in Review
Volume31
Issue number10
DOIs
StatePublished - Oct 2010

Fingerprint

Exocrine Pancreatic Insufficiency
Enterocytes
Abetalipoproteinemia
Fats
Facilitated Diffusion
Lactose Intolerance
Hypoproteinemia
Failure to Thrive
Active Biological Transport
Chronic Pancreatitis
Intestinal Mucosa
Endocytosis
Cystic Fibrosis
Bile
Physical Examination
Edema
History
Carbohydrates
Amino Acids
Food

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Malabsorptive disorders of childhood. / Ammoury, Rana F.; Croffie, Joseph.

In: Pediatrics in Review, Vol. 31, No. 10, 10.2010, p. 407-416.

Research output: Contribution to journalArticle

Ammoury, Rana F. ; Croffie, Joseph. / Malabsorptive disorders of childhood. In: Pediatrics in Review. 2010 ; Vol. 31, No. 10. pp. 407-416.
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