Male predominance in childhood ischemic stroke

Findings from the international pediatric stroke study

Meredith Golomb, Heather J. Fullerton, Ulrike Nowak-Gottl, Gabrielle Deveber

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Previous studies suggested a male predominance in childhood ischemic stroke, mirroring gender differences in adults but were limited by small sample sizes or unconfirmed diagnoses. We sought to study gender within a large international series of confirmed cases of pediatric ischemic stroke. METHODS: From January 2003 to July 2007, the International Pediatric Stroke Study enrolled children (0 up to 19 years) with arterial ischemic stroke or cerebral sinovenous thrombosis at 30 centers in 10 countries. Neonates were those <29 days of age. We calculated the "expected" gender ratio for our study as the weighted average of population-based childhood gender ratios in enrolling countries weighted by the number of subjects enrolled in each country. χ 2 tests were used to compare the observed gender ratios in our series with this expected ratio (51.7%). RESULTS: Among 1187 children with confirmed ischemic stroke, 710 were boys (60%, P<0.0001). Male predominance persisted after stratification by age (61% for neonates, P≤0.011; 59% for later childhood, P≤0.002) and stroke subtype (58% for arterial ischemic stroke, P≤0.004; 65% for cerebral sinovenous thrombosis, P≤0.002). The greatest proportion of males occurred among children with arterial ischemic stroke and a history of trauma (75%, P≤0.008), although boys were also overrepresented among those with arterial ischemic stroke and no trauma (57%; P≤0.07). There were no gender differences in case fatality or deficits at discharge. CONCLUSIONS: Childhood ischemic stroke appears to be more common in boys regardless of age, stroke subtype, or history of trauma. Further exploration of this gender difference could shed light on stroke mechanisms in both children and adults.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalStroke
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2009

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Stroke
Pediatrics
Intracranial Thrombosis
Wounds and Injuries
Newborn Infant
Sample Size
Population

Keywords

  • Child
  • Sex distribution
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Medicine(all)

Cite this

Male predominance in childhood ischemic stroke : Findings from the international pediatric stroke study. / Golomb, Meredith; Fullerton, Heather J.; Nowak-Gottl, Ulrike; Deveber, Gabrielle.

In: Stroke, Vol. 40, No. 1, 01.01.2009, p. 52-57.

Research output: Contribution to journalArticle

Golomb, Meredith ; Fullerton, Heather J. ; Nowak-Gottl, Ulrike ; Deveber, Gabrielle. / Male predominance in childhood ischemic stroke : Findings from the international pediatric stroke study. In: Stroke. 2009 ; Vol. 40, No. 1. pp. 52-57.
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