Malignant abdominal mesothelioma: Defining the role of surgery

Dayron Rodríguez, Michael C. Cheung, Nadine Housri, Leonidas G. Koniaris

Research output: Contribution to journalArticle

36 Scopus citations


Objective: Determine the role of surgery for patients with malignant abdominal mesotheliomas (MAMs). Methods: The Surveillance, Epidemiology, and End Results (SEER) database (1973-2005) was queried. Results: Overall, 10,589 cases of malignant mesotheliomas were identified. Of these, 9,211 cases were thoracic (TM) and 1,112 cases were MAM (10.5%). Patients with TM presented with more localized disease than those patients with MAM (P < 0.001). MAM more often affected younger patients (63 years vs. 71 years) (P < 0.001). The annual incidence of MAM was approximately 1.00 case per 100,000 in 2005. Overall median survival for MAM patients was 8 months, with a significant difference between women and men (13 months vs. 6 months, respectively) (P < 0.001). Patients who successfully underwent surgical resection had a considerably longer median survival (20 months vs. 4 months, P < 0.001) as well as a significantly higher 5-year survival (28% vs. 12%, P < 0.001). Multivariate analysis identified that a poorly differentiated tumor grade, failure to undertake surgical resection, advanced age, and male gender were all independent predictors of poorer outcome. Conclusion: Surgical extirpation of MAM may be associated with significantly improved survival. All patients with MAM should be evaluated for potential surgical resection.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalJournal of Surgical Oncology
Issue number1
StatePublished - Jan 1 2009
Externally publishedYes


  • Abdominal mesothelioma
  • Cancer
  • Malignancy
  • Outcomes
  • Peritoneal mesothelioma
  • Pleural mesothelioma
  • SEER
  • Surgery
  • Survival
  • Thoracic mesothelioma

ASJC Scopus subject areas

  • Surgery
  • Oncology

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