Malignant disorders of megakaryocytes

Larry Cripe, R. Hromas

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Among hematologic malignancies, there are three disorders whose behavior is governed principally by the abnormal proliferation of a malignant megakaryocytic clone or a product thereof. These disorders are essential thrombocythemia, agnogenic myeloid metaplasia, and acute megakaryoblastic leukemia. Although there are other myeloproliferative diseases that can have high platelet counts, the major pathobiology of those diseases most commonly results from the proliferation of other hematopoietic lineages. Despite the rarity of the three disorders of malignant megakaryopoiesis mentioned above, advances have been made in the diagnosis, prognosis, and treatment of these disorders in recent years. However, understanding of the cellular and especially molecular pathobiology lags far behind.

Original languageEnglish
Pages (from-to)200-209
Number of pages10
JournalSeminars in Hematology
Volume35
Issue number3
StatePublished - 1998

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Megakaryocytes
Leukemia, Megakaryoblastic, Acute
Essential Thrombocythemia
Primary Myelofibrosis
Hematologic Neoplasms
Platelet Count
Clone Cells

ASJC Scopus subject areas

  • Hematology

Cite this

Malignant disorders of megakaryocytes. / Cripe, Larry; Hromas, R.

In: Seminars in Hematology, Vol. 35, No. 3, 1998, p. 200-209.

Research output: Contribution to journalArticle

Cripe, L & Hromas, R 1998, 'Malignant disorders of megakaryocytes', Seminars in Hematology, vol. 35, no. 3, pp. 200-209.
Cripe, Larry ; Hromas, R. / Malignant disorders of megakaryocytes. In: Seminars in Hematology. 1998 ; Vol. 35, No. 3. pp. 200-209.
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