Malignant fibrous histiocytoma of the glans penis

A case report

Terrence M. Katona, Alan J. Shienbaum, Larry L. Wyatt, Gordon A. Brown, Liang Cheng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

BACKGROUND: Malignant fibrous histiocytoma has been regarded as the most common sarcoma of older adults. However, recent opinion regards pleomorphic malignant fibrous histiocytoma as an undifferentiated high grade pleomorphic sarcoma not otherwise classifiable utilizing current techniques available in surgical pathology. Notwithstanding controversy regarding its nomenclature, malignant fibrous histiocytoma involving the penis is exceedingly rare, with only 4 cases previously described, to our knowledge. CASE: An uncircumcised 73-year-old male presented with a painless, granular, partially necrotic lesion beneath the penile foreskin. There was no history of sexually transmitted disease, constitutional symptoms or dysuria. Examination of penile shaft, testicles, spermatic cord and inguinal lymph nodes were unremarkable. Biopsy revealed a markedly pleomorphic sarcoma. Subsequent, partial penectomy revealed the same lesion with an adjacent area of squamous cell carcinoma in situ. CONCLUSION: Malignant fibrous histiocytoma remains a diagnosis of exclusion. The investigation requires extensive tumor sampling in search of areas of differentiation and a complete battery of immunohistochemical markers. Therapeutically important entities in the differential diagnosis that must be ruled out include other poorly differentiated sarcomas, sarcomatoid squamous cell carcinoma and desmoplastic melanoma.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalAnalytical and Quantitative Cytology and Histology
Volume28
Issue number1
StatePublished - Feb 2006

Fingerprint

Malignant Fibrous Histiocytoma
Penis
Sarcoma
Squamous Cell Carcinoma
Spermatic Cord
Foreskin
Dysuria
Surgical Pathology
Groin
Carcinoma in Situ
Sexually Transmitted Diseases
Terminology
Testis
Melanoma
Differential Diagnosis
Lymph Nodes
Biopsy
Neoplasms

Keywords

  • Malignant fibrous histiocytoma
  • Neoplasia
  • Penis
  • Sarcoma
  • Soft tissue tumor

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Cell Biology

Cite this

Katona, T. M., Shienbaum, A. J., Wyatt, L. L., Brown, G. A., & Cheng, L. (2006). Malignant fibrous histiocytoma of the glans penis: A case report. Analytical and Quantitative Cytology and Histology, 28(1), 39-42.

Malignant fibrous histiocytoma of the glans penis : A case report. / Katona, Terrence M.; Shienbaum, Alan J.; Wyatt, Larry L.; Brown, Gordon A.; Cheng, Liang.

In: Analytical and Quantitative Cytology and Histology, Vol. 28, No. 1, 02.2006, p. 39-42.

Research output: Contribution to journalArticle

Katona, TM, Shienbaum, AJ, Wyatt, LL, Brown, GA & Cheng, L 2006, 'Malignant fibrous histiocytoma of the glans penis: A case report', Analytical and Quantitative Cytology and Histology, vol. 28, no. 1, pp. 39-42.
Katona, Terrence M. ; Shienbaum, Alan J. ; Wyatt, Larry L. ; Brown, Gordon A. ; Cheng, Liang. / Malignant fibrous histiocytoma of the glans penis : A case report. In: Analytical and Quantitative Cytology and Histology. 2006 ; Vol. 28, No. 1. pp. 39-42.
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