Management of Difficult Cases of Autoimmune Hepatitis

Craig Lammert, Veronica M. Loy, Kiyoko Oshima, Samer Gawrieh

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Autoimmune hepatitis (AIH) is a complex autoimmune disease characterized by immune-mediated destruction of hepatic parenchyma which can result in cirrhosis, liver failure, and death. Current American Association for the Study of Liver Diseases (AASLD) and European Association for the Study of Liver (EASL) guidelines recommend corticosteroids alone or in combination with azathioprine as first-line treatment strategies. However, a significant proportion of patients may not be able to tolerate or achieve complete biochemical response with these options. In this article, we discuss approaches to these patients and other challenging AIH patient groups such as the asymptomatic, pregnant, elderly, and liver transplant recipients.

Original languageEnglish (US)
Article number9
Pages (from-to)1-9
Number of pages9
JournalCurrent gastroenterology reports
Volume18
Issue number2
DOIs
StatePublished - Jan 1 2016

Keywords

  • Autoimmune hepatitis
  • Cirrhosis
  • Liver transplantation
  • Nonstandard treatment
  • Pregnancy
  • Refractory

ASJC Scopus subject areas

  • Gastroenterology

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