Mapping cortical atrophy in parkinson's disease patients with dementia

Kristy S. Hwang, Mona K. Beyer, Amity E. Green, Christine Chung, Paul M. Thompson, Carmen Janvin, Jan P. Larsen, Dag Aarsland, Liana G. Apostolova

Research output: Contribution to journalArticle

Abstract

Background: Cognitive impairment is very common in patients with Parkinson's disease (PD). Brain changes accompanying cognitive decline in PD are still not fully established. Methods: We applied cortical pattern matching and cortical thickness analyses to the three-dimensional T1-weighted brain MRI scans of 14 age-matched cognitively normal elderly (NC), 12 cognitively normal PD (PDC), and 11 PD dementia (PDD) subjects. We used linear regression models to investigate the effect of diagnosis on cortical thickness. All maps were adjusted for multiple comparisons using permutation testing with a threshold p < 0.01. Results: PDD showed significantly thinner bilateral sensorimotor, perisylvian, lateral parietal, as well as right posterior cingulate, parieto-occipital, inferior temporal and lateral frontal cortices relative to NC (left pcorrected = 0.06, right pcorrected = 0.009). PDD showed significantly thinner bilateral sensorimotor, right frontal and right parietal-occipital cortices relative to PDC (right pcorrected = 0.05). The absolute difference in cortical thickness between PDD and the other diagnostic groups ranged from 3% to 19%. Conclusion: Our data shows that cognitive decline in PD is associated with cortical atrophy. PDD subjects have the most widespread gray matter atrophy suggesting more cortical involvement as PD patients progress to dementia.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalJournal of Parkinson's Disease
Volume3
Issue number1
DOIs
StatePublished - Jul 22 2013

Fingerprint

Atrophy
Parkinson Disease
Dementia
Linear Models
Occipital Lobe
Parietal Lobe
Gyrus Cinguli
Brain
Frontal Lobe
Magnetic Resonance Imaging
Cognitive Dysfunction

Keywords

  • MRI
  • Parkinson's disease
  • brain atrophy
  • cortical atrophy
  • dementia
  • gray matter atrophy
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Hwang, K. S., Beyer, M. K., Green, A. E., Chung, C., Thompson, P. M., Janvin, C., ... Apostolova, L. G. (2013). Mapping cortical atrophy in parkinson's disease patients with dementia. Journal of Parkinson's Disease, 3(1), 69-76. https://doi.org/10.3233/JPD-120151

Mapping cortical atrophy in parkinson's disease patients with dementia. / Hwang, Kristy S.; Beyer, Mona K.; Green, Amity E.; Chung, Christine; Thompson, Paul M.; Janvin, Carmen; Larsen, Jan P.; Aarsland, Dag; Apostolova, Liana G.

In: Journal of Parkinson's Disease, Vol. 3, No. 1, 22.07.2013, p. 69-76.

Research output: Contribution to journalArticle

Hwang, KS, Beyer, MK, Green, AE, Chung, C, Thompson, PM, Janvin, C, Larsen, JP, Aarsland, D & Apostolova, LG 2013, 'Mapping cortical atrophy in parkinson's disease patients with dementia', Journal of Parkinson's Disease, vol. 3, no. 1, pp. 69-76. https://doi.org/10.3233/JPD-120151
Hwang KS, Beyer MK, Green AE, Chung C, Thompson PM, Janvin C et al. Mapping cortical atrophy in parkinson's disease patients with dementia. Journal of Parkinson's Disease. 2013 Jul 22;3(1):69-76. https://doi.org/10.3233/JPD-120151
Hwang, Kristy S. ; Beyer, Mona K. ; Green, Amity E. ; Chung, Christine ; Thompson, Paul M. ; Janvin, Carmen ; Larsen, Jan P. ; Aarsland, Dag ; Apostolova, Liana G. / Mapping cortical atrophy in parkinson's disease patients with dementia. In: Journal of Parkinson's Disease. 2013 ; Vol. 3, No. 1. pp. 69-76.
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