Mapping of local conduction anisotropy in the ischemic myocardium

Dietrich Romberg, R. Mass, M. Biermann, D. P. Zipes, E. J. Berbari

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effects of angiotensin II (Ang II), a modulator of cellular coupling, on impulse propagation in the ischemic myocardium were analyzed using maps of local conduction anisotropy. In control studies, ischemia causes a reduction in conduction velocities for both directions without significant changes for the anisotropic ratio. Before ischemia, Ang II induces an increase in the longitudinal direction but a decrease in the transversal direction. During ischemia, in the Ang II experiments conduction velocity slowed more rapidly and, reached slower conduction values for the transverse direction than in the controls. Conclusions: In the ischemic myocardium, Ang II enhances nonuniform anisotropy and hastens the development of conduction block. Thus, the therapeutic effect of ACE-inhibitors in patients with myocardial infarction may include an antiarrhythmic action.

Original languageEnglish
Title of host publicationComputers in Cardiology
PublisherIEEE
Pages285-287
Number of pages3
StatePublished - 1999
EventThe 26th Annual Meeting: Computers in Cardiology 1999 - Hannover, Ger
Duration: Sep 26 1999Sep 29 1999

Other

OtherThe 26th Annual Meeting: Computers in Cardiology 1999
CityHannover, Ger
Period9/26/999/29/99

Fingerprint

Anisotropy
Angiotensin II
Myocardium
Ischemia
Modulators
Therapeutic Uses
Angiotensin-Converting Enzyme Inhibitors
Experiments
Myocardial Infarction
Direction compound

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Romberg, D., Mass, R., Biermann, M., Zipes, D. P., & Berbari, E. J. (1999). Mapping of local conduction anisotropy in the ischemic myocardium. In Computers in Cardiology (pp. 285-287). IEEE.

Mapping of local conduction anisotropy in the ischemic myocardium. / Romberg, Dietrich; Mass, R.; Biermann, M.; Zipes, D. P.; Berbari, E. J.

Computers in Cardiology. IEEE, 1999. p. 285-287.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Romberg, D, Mass, R, Biermann, M, Zipes, DP & Berbari, EJ 1999, Mapping of local conduction anisotropy in the ischemic myocardium. in Computers in Cardiology. IEEE, pp. 285-287, The 26th Annual Meeting: Computers in Cardiology 1999, Hannover, Ger, 9/26/99.
Romberg D, Mass R, Biermann M, Zipes DP, Berbari EJ. Mapping of local conduction anisotropy in the ischemic myocardium. In Computers in Cardiology. IEEE. 1999. p. 285-287
Romberg, Dietrich ; Mass, R. ; Biermann, M. ; Zipes, D. P. ; Berbari, E. J. / Mapping of local conduction anisotropy in the ischemic myocardium. Computers in Cardiology. IEEE, 1999. pp. 285-287
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