Markers of renal disease and function are associated with systemic inflammation in HIV infection

AIDS Clinical Trials Group Study A5224s Team

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: Both renal disease and systemic inflammation predict non-AIDS-defining events and overall mortality in HIV-infected patients. Here, we sought to determine the relationships between renal disease and circulating inflammation markers. Methods: We performed a secondary analysis of AIDS Clinical Trials Group Study A5224s to determine if markers of renal disease [urine protein:creatinine ratio (uPCR), urine albumin:creatinine ratio (uACR), and estimated glomerular filtration rate (eGFR), using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine and cystatin C-creatinine] were associated with markers of systemic inflammation [high-sensitivity C-reactive protein, interleukin-6, tumour necrosis factor (TNF)-α, soluble TNF-α receptor I (sTNFRI), sTNFRII, and soluble vascular cellular and intercellular adhesion molecules]. We correlated these renal and inflammatory markers prior to antiretroviral initiation and after 96 weeks of therapy. Results: We found that eGFR (estimated using CKD-EPI cystatin C-creatinine), uPCR, and uACR were significantly correlated with most assessed markers of systemic inflammation prior to antiretroviral initiation. uPCR and eGFR (using CKD-EPI cystatin C-creatinine), but not uACR, remained significantly correlated with most of the assessed inflammatory markers after 96 weeks of antiretroviral therapy (ART). Most of these correlations, although statistically significant, were

Original languageEnglish (US)
Pages (from-to)591-598
Number of pages8
JournalHIV Medicine
Volume16
Issue number10
DOIs
StatePublished - Nov 1 2015

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HIV Infections
Creatinine
Inflammation
Kidney
Urine
Cystatin C
Glomerular Filtration Rate
Chronic Renal Insufficiency
Albumins
Epidemiology
Proteins
Tumor Necrosis Factor Receptors
Cell Adhesion Molecules
C-Reactive Protein
Blood Vessels
Interleukin-6
Acquired Immunodeficiency Syndrome
Tumor Necrosis Factor-alpha
Clinical Trials
HIV

Keywords

  • Albuminuria
  • HIV-1
  • Inflammation
  • Nephropathy
  • Proteinuria

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Health Policy

Cite this

Markers of renal disease and function are associated with systemic inflammation in HIV infection. / AIDS Clinical Trials Group Study A5224s Team.

In: HIV Medicine, Vol. 16, No. 10, 01.11.2015, p. 591-598.

Research output: Contribution to journalArticle

AIDS Clinical Trials Group Study A5224s Team. / Markers of renal disease and function are associated with systemic inflammation in HIV infection. In: HIV Medicine. 2015 ; Vol. 16, No. 10. pp. 591-598.
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