Masticatory movements and EMG activity following electrolytic lesions of the trigeminal motor nucleus in growing guinea pigs

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Abstract

Unilateral electrolytic lesions were produced in the left trigeminal motor nucleus (TMN) of six guinea pigs at 49 days of age. Masticatory mandibular movement and EMG data were collected prior to lesioning and at 4 and 12 days postlesion. After the animals were killed 60 days postlesion, dissection and maceration revealed muscular atrophy and craniofacial asymmetries on the lesion side. Analyses of prelesion and postlesion mandibular movement and EMG data indicated significant (p < 0.05; p < 0.01) changes in chew cycle durations, dimensions, and EMG activity patterns. Shifts in EMG durations of working- and balancing-side muscles were strongly related to most of the observed skeletal asymmetries. Data indicated that muscular paresis and altered neuromuscular activity can effect skeletal changes in the mammalian craniofacial complex; total muscular paralysis is not a prerequisite for profound morphologic changes. Altered manifestation of masticatory central pattern generators within the central nervous system may also account for variations in craniofacial form and function.

Original languageEnglish
Pages (from-to)146-161
Number of pages16
JournalAmerican Journal of Orthodontics
Volume86
Issue number2
DOIs
StatePublished - 1984
Externally publishedYes

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Central Pattern Generators
Muscular Atrophy
Paresis
Paralysis
Dissection
Guinea Pigs
Central Nervous System
Muscles
Trigeminal Motor Nucleus

Keywords

  • Electromyography
  • mastication
  • morphogenesis
  • paresis
  • trigeminal

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

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abstract = "Unilateral electrolytic lesions were produced in the left trigeminal motor nucleus (TMN) of six guinea pigs at 49 days of age. Masticatory mandibular movement and EMG data were collected prior to lesioning and at 4 and 12 days postlesion. After the animals were killed 60 days postlesion, dissection and maceration revealed muscular atrophy and craniofacial asymmetries on the lesion side. Analyses of prelesion and postlesion mandibular movement and EMG data indicated significant (p < 0.05; p < 0.01) changes in chew cycle durations, dimensions, and EMG activity patterns. Shifts in EMG durations of working- and balancing-side muscles were strongly related to most of the observed skeletal asymmetries. Data indicated that muscular paresis and altered neuromuscular activity can effect skeletal changes in the mammalian craniofacial complex; total muscular paralysis is not a prerequisite for profound morphologic changes. Altered manifestation of masticatory central pattern generators within the central nervous system may also account for variations in craniofacial form and function.",
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