Maternal ethnicity influences on neonatal respiratory outcomes after antenatal corticosteroid use for anticipated preterm delivery

David Haas, Adam C. Sischy, William McCullough, Amanda J. Simsiman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective. To explore the influence of maternal ethnicity on neonatal outcomes after antenatal corticosteroid administration. Methods. A retrospective review of ethnicity, maternal factors, and neonatal birth outcomes was performed for preterm births at a single institution. Cases were limited to women who received antenatal corticosteroids. The impact of ethnicity on specific neonatal respiratory outcomes and mortality was analyzed by bivariate comparisons and by logistic regression analysis. Results. Complete ethnicity data were obtained for 548 women. Controlling for gestational age at delivery, diabetes, whether the subject completed a course of steroids, and the dosing of the steroids, logistic regression demonstrated that ethnicity was independently associated with respiratory distress syndrome (compared to Caucasians: African-Americans OR 0.49 (95% CI 0.29-0.85); Filipinos OR 0.45 (95% CI 0.21-0.96). Conclusions. Ethnicity is independently associated with neonatal respiratory outcomes after antenatal corticosteroid use. Perhaps individualized dosing of antenatal corticosteroids is needed to further improve neonatal outcomes.

Original languageEnglish
Pages (from-to)516-520
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume24
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Adrenal Cortex Hormones
Mothers
Logistic Models
Steroids
Premature Birth
African Americans
Gestational Age
Regression Analysis
Parturition
Mortality

Keywords

  • Betamethasone
  • ethnicity
  • preterm birth
  • respiratory distress syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Maternal ethnicity influences on neonatal respiratory outcomes after antenatal corticosteroid use for anticipated preterm delivery. / Haas, David; Sischy, Adam C.; McCullough, William; Simsiman, Amanda J.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 24, No. 3, 03.2011, p. 516-520.

Research output: Contribution to journalArticle

@article{463ef2fd914e410e840fe8049811b3d7,
title = "Maternal ethnicity influences on neonatal respiratory outcomes after antenatal corticosteroid use for anticipated preterm delivery",
abstract = "Objective. To explore the influence of maternal ethnicity on neonatal outcomes after antenatal corticosteroid administration. Methods. A retrospective review of ethnicity, maternal factors, and neonatal birth outcomes was performed for preterm births at a single institution. Cases were limited to women who received antenatal corticosteroids. The impact of ethnicity on specific neonatal respiratory outcomes and mortality was analyzed by bivariate comparisons and by logistic regression analysis. Results. Complete ethnicity data were obtained for 548 women. Controlling for gestational age at delivery, diabetes, whether the subject completed a course of steroids, and the dosing of the steroids, logistic regression demonstrated that ethnicity was independently associated with respiratory distress syndrome (compared to Caucasians: African-Americans OR 0.49 (95{\%} CI 0.29-0.85); Filipinos OR 0.45 (95{\%} CI 0.21-0.96). Conclusions. Ethnicity is independently associated with neonatal respiratory outcomes after antenatal corticosteroid use. Perhaps individualized dosing of antenatal corticosteroids is needed to further improve neonatal outcomes.",
keywords = "Betamethasone, ethnicity, preterm birth, respiratory distress syndrome",
author = "David Haas and Sischy, {Adam C.} and William McCullough and Simsiman, {Amanda J.}",
year = "2011",
month = "3",
doi = "10.3109/14767058.2010.506228",
language = "English",
volume = "24",
pages = "516--520",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Maternal ethnicity influences on neonatal respiratory outcomes after antenatal corticosteroid use for anticipated preterm delivery

AU - Haas, David

AU - Sischy, Adam C.

AU - McCullough, William

AU - Simsiman, Amanda J.

PY - 2011/3

Y1 - 2011/3

N2 - Objective. To explore the influence of maternal ethnicity on neonatal outcomes after antenatal corticosteroid administration. Methods. A retrospective review of ethnicity, maternal factors, and neonatal birth outcomes was performed for preterm births at a single institution. Cases were limited to women who received antenatal corticosteroids. The impact of ethnicity on specific neonatal respiratory outcomes and mortality was analyzed by bivariate comparisons and by logistic regression analysis. Results. Complete ethnicity data were obtained for 548 women. Controlling for gestational age at delivery, diabetes, whether the subject completed a course of steroids, and the dosing of the steroids, logistic regression demonstrated that ethnicity was independently associated with respiratory distress syndrome (compared to Caucasians: African-Americans OR 0.49 (95% CI 0.29-0.85); Filipinos OR 0.45 (95% CI 0.21-0.96). Conclusions. Ethnicity is independently associated with neonatal respiratory outcomes after antenatal corticosteroid use. Perhaps individualized dosing of antenatal corticosteroids is needed to further improve neonatal outcomes.

AB - Objective. To explore the influence of maternal ethnicity on neonatal outcomes after antenatal corticosteroid administration. Methods. A retrospective review of ethnicity, maternal factors, and neonatal birth outcomes was performed for preterm births at a single institution. Cases were limited to women who received antenatal corticosteroids. The impact of ethnicity on specific neonatal respiratory outcomes and mortality was analyzed by bivariate comparisons and by logistic regression analysis. Results. Complete ethnicity data were obtained for 548 women. Controlling for gestational age at delivery, diabetes, whether the subject completed a course of steroids, and the dosing of the steroids, logistic regression demonstrated that ethnicity was independently associated with respiratory distress syndrome (compared to Caucasians: African-Americans OR 0.49 (95% CI 0.29-0.85); Filipinos OR 0.45 (95% CI 0.21-0.96). Conclusions. Ethnicity is independently associated with neonatal respiratory outcomes after antenatal corticosteroid use. Perhaps individualized dosing of antenatal corticosteroids is needed to further improve neonatal outcomes.

KW - Betamethasone

KW - ethnicity

KW - preterm birth

KW - respiratory distress syndrome

UR - http://www.scopus.com/inward/record.url?scp=79751503095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79751503095&partnerID=8YFLogxK

U2 - 10.3109/14767058.2010.506228

DO - 10.3109/14767058.2010.506228

M3 - Article

VL - 24

SP - 516

EP - 520

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 3

ER -