Maternal exposure to N-nitrosatable drugs as a risk factor for childhood brain tumours

Susan E. Carozza, Andrew F. Olshan, Elaine M. Faustman, Mary J. Gula, Laurence N. Kolonel, Donald F. Austin, E. Dee West, Noel S. Weiss, G. Marie Swanson, Joseph L. Lyon, Tessa Hedley-whyte, Floyd H. Gilles, Carol Aschenbrener, Alan Leviton

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. Animal models suggest that compounds containing a nitrosyl group (N-nitroso compounds (NNO)) can act as potent transplacental carcinogens. Many common drug formulations have the potential to undergo nitrosation in vivo. The association between maternal use of nitrosatable drugs during pregnancy and development of brain tumours in the offspring was examined in a SEER-based case-control study.Methods. Maternal exposure to nitrosatable drugs during pregnancy was compared among 361 childhood brain tumour cases and 1083 matched controls recruited through random-digit dialling.Results. There was no increase in risk observed for childhood brain tumours overall (OR = 1.15; 95% Cl : 0.69-1.94) or for astrocytomas individually (OR = 1.16; 95% Cl : 0.50-2.69). A slight elevation in risk was noted for medulloblastomas (OR = 1.47; 95% Cl : 0.28-7.62) and 'other' tumours (OR = 1.27; 95% Cl : 0.56-2.86), however, both estimates were based on small numbers.Conclusions. Our findings suggest that no increased risk of childhood brain tumours was associated with maternal exposure to nitrosatable drugs. The study results should be viewed with caution given the imprecision of the point estimates as well as the lack of data on specific timing and dosage of exposure and degree of nltrosatability of drugs taken.

Original languageEnglish (US)
Pages (from-to)308-312
Number of pages5
JournalInternational Journal of Epidemiology
Volume24
Issue number2
DOIs
StatePublished - Apr 1995
Externally publishedYes

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Maternal Exposure
Brain Tumor
Risk Factors
Brain Neoplasms
Tumors
Brain
Drugs
Pharmaceutical Preparations
Pregnancy
Nitrosation
Nitroso Compounds
Drug Compounding
Medulloblastoma
Astrocytoma
Animal Model
Carcinogens
Point Estimate
Case-control Study
Imprecision
Case-Control Studies

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Epidemiology

Cite this

Carozza, S. E., Olshan, A. F., Faustman, E. M., Gula, M. J., Kolonel, L. N., Austin, D. F., ... Leviton, A. (1995). Maternal exposure to N-nitrosatable drugs as a risk factor for childhood brain tumours. International Journal of Epidemiology, 24(2), 308-312. https://doi.org/10.1093/ije/24.2.308

Maternal exposure to N-nitrosatable drugs as a risk factor for childhood brain tumours. / Carozza, Susan E.; Olshan, Andrew F.; Faustman, Elaine M.; Gula, Mary J.; Kolonel, Laurence N.; Austin, Donald F.; West, E. Dee; Weiss, Noel S.; Swanson, G. Marie; Lyon, Joseph L.; Hedley-whyte, Tessa; Gilles, Floyd H.; Aschenbrener, Carol; Leviton, Alan.

In: International Journal of Epidemiology, Vol. 24, No. 2, 04.1995, p. 308-312.

Research output: Contribution to journalArticle

Carozza, SE, Olshan, AF, Faustman, EM, Gula, MJ, Kolonel, LN, Austin, DF, West, ED, Weiss, NS, Swanson, GM, Lyon, JL, Hedley-whyte, T, Gilles, FH, Aschenbrener, C & Leviton, A 1995, 'Maternal exposure to N-nitrosatable drugs as a risk factor for childhood brain tumours', International Journal of Epidemiology, vol. 24, no. 2, pp. 308-312. https://doi.org/10.1093/ije/24.2.308
Carozza, Susan E. ; Olshan, Andrew F. ; Faustman, Elaine M. ; Gula, Mary J. ; Kolonel, Laurence N. ; Austin, Donald F. ; West, E. Dee ; Weiss, Noel S. ; Swanson, G. Marie ; Lyon, Joseph L. ; Hedley-whyte, Tessa ; Gilles, Floyd H. ; Aschenbrener, Carol ; Leviton, Alan. / Maternal exposure to N-nitrosatable drugs as a risk factor for childhood brain tumours. In: International Journal of Epidemiology. 1995 ; Vol. 24, No. 2. pp. 308-312.
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AU - Olshan, Andrew F.

AU - Faustman, Elaine M.

AU - Gula, Mary J.

AU - Kolonel, Laurence N.

AU - Austin, Donald F.

AU - West, E. Dee

AU - Weiss, Noel S.

AU - Swanson, G. Marie

AU - Lyon, Joseph L.

AU - Hedley-whyte, Tessa

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AU - Aschenbrener, Carol

AU - Leviton, Alan

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