Measles virus vaccination of adults seropositive for measles resulted in suppression of chemotactic factor production in response to concanavalin A (Con A), purified protein derivative (PPD), and purified measles virus antigen, and of lymphoproliferative responses to high doses of phytohemagglutinin (PHA). Persons receiving the vaccine had no clinical signs of infection, no detectable viremia, and no rise in antibody titers to measles virus. The suppression of both chemotactic factor production and lymphoproliferation was of shorter duration than that observed in studies of acute measles virus infection. Suppression could not be related to increases in the number of circulating cells capable of suppressing the Con A or PHA responses of normal lymphocytes. These studies indicate that measles virus may cause immunosuppression in the absence of detectable virus replication in mononuclear cells.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine