Measles virus vaccination of measles seropositive individuals suppresses lymphocyte proliferation and chemotactic factor production

Robert L. Hirsch, Foroozan Mokhtarian, Diane E. Griffin, Benjamin Rix Brooks, Jay Hess, Richard T. Johnson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Measles virus vaccination of adults seropositive for measles resulted in suppression of chemotactic factor production in response to concanavalin A (Con A), purified protein derivative (PPD), and purified measles virus antigen, and of lymphoproliferative responses to high doses of phytohemagglutinin (PHA). Persons receiving the vaccine had no clinical signs of infection, no detectable viremia, and no rise in antibody titers to measles virus. The suppression of both chemotactic factor production and lymphoproliferation was of shorter duration than that observed in studies of acute measles virus infection. Suppression could not be related to increases in the number of circulating cells capable of suppressing the Con A or PHA responses of normal lymphocytes. These studies indicate that measles virus may cause immunosuppression in the absence of detectable virus replication in mononuclear cells.

Original languageEnglish (US)
Pages (from-to)341-350
Number of pages10
JournalClinical Immunology and Immunopathology
Volume21
Issue number3
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Measles virus
Measles
Vaccination
Chemotactic Factors
Phytohemagglutinins
Concanavalin A
Viremia
Virus Diseases
Virus Replication
Immunosuppression
Vaccines
Cell Count
lymphotactin
Lymphocytes
Antigens
Antibodies
Infection
Proteins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Measles virus vaccination of measles seropositive individuals suppresses lymphocyte proliferation and chemotactic factor production. / Hirsch, Robert L.; Mokhtarian, Foroozan; Griffin, Diane E.; Brooks, Benjamin Rix; Hess, Jay; Johnson, Richard T.

In: Clinical Immunology and Immunopathology, Vol. 21, No. 3, 1981, p. 341-350.

Research output: Contribution to journalArticle

Hirsch, Robert L. ; Mokhtarian, Foroozan ; Griffin, Diane E. ; Brooks, Benjamin Rix ; Hess, Jay ; Johnson, Richard T. / Measles virus vaccination of measles seropositive individuals suppresses lymphocyte proliferation and chemotactic factor production. In: Clinical Immunology and Immunopathology. 1981 ; Vol. 21, No. 3. pp. 341-350.
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