Measurement of antiretroviral drugs in the lungs of HIV-infected patients

Homer L. Twigg, Carol T. Schnizlein-Bick, Michael Weiden, Fred Valentine, Joseph Wheat, Richard B. Day, Helen Rominger, Lu Zheng, Ronald G. Collman, Robert W. Coombs, R. Pat Bucy, Naser L. Rezk, Ngela DM Kashuba

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Aims: Prior studies have shown that HAART is associated with decreased HIV viral load in the lungs. The correlation between antiretroviral exposure in bronchoalveolar lavage (BAL) fluid and virologic response was evaluated in patients starting HAART and enrolled in The AIDS Clinical Trial Group Protocol 723. Materials & methods: A total of 24 subjects underwent blood and BAL sampling prior to starting HAART, and after 4 and 24 weeks of HAART. Drug concentrations and HIV RNA were measured in paired plasma and BAL samples. Results: Antiretroviral drugs, including efavirenz, were detectable in BAL fluid of HIV-infected subjects beginning HAART. Efavirenz was also associated with a higher likelihood of clearing HIV RNA from the lungs. Conclusion: These results suggest the excellent pulmonary virologic response to antiretroviral therapy may, in part, be due to penetration of antiretroviral drugs into the alveolar compartment.

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalHIV Therapy
Volume4
Issue number2
DOIs
StatePublished - Mar 1 2010

    Fingerprint

Keywords

  • Bronchoalveolar lavage
  • Drug concentration
  • Efavirenz
  • HAART
  • HIV RNA
  • Lung

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology
  • Dermatology

Cite this

Twigg, H. L., Schnizlein-Bick, C. T., Weiden, M., Valentine, F., Wheat, J., Day, R. B., Rominger, H., Zheng, L., Collman, R. G., Coombs, R. W., Bucy, R. P., Rezk, N. L., & Kashuba, N. DM. (2010). Measurement of antiretroviral drugs in the lungs of HIV-infected patients. HIV Therapy, 4(2), 247-251. https://doi.org/10.2217/hiv.10.5