Measurement of liver volume using spiral CT and the curved line and cubic spline algorithms: Reproducibility and interobserver variation

K. Sandrasegaran, P. W. Kwo, D. DiGirolamo, S. M. Stockberger, O. W. Cummings, K. K. Kopecky

Research output: Contribution to journalArticle

46 Scopus citations


Background: The purpose of this article was to evaluate the accuracy and reproducibility of spiral computed tomography (CT) and the curved line and cubic spline algorithms in measuring liver volume. Methods: Spiral CT was performed in phantoms, cadaveric liver specimens, and 35 live human subjects (19 healthy volunteers and 16 patients). Images were transferred to a workstation, and volumes were measured by two observers. One observer repeated the measurements at a separate sitting. Results: The correlation between the CT measurement and the gold standard measurement of the cadaveric livers was very strong (r = 0.94). For the live human subjects, the intraobserver and interobserver correlations were extremely high (r = 0.999 and 0.997, respectively). The mean difference in liver volume measurements between the separate observations was 1%. Conclusion: The accuracy and reproducibility of this method of assessing liver volume are very high.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalAbdominal Imaging
Issue number1
StatePublished - Jan 1 1999



  • Computed tomography (CT), computer programs
  • Computed tomography (CT), image processing
  • Computed tomography (CT), quantitative
  • Liver, CT
  • Volume measurement

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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