Measurement of nutrient intake by deuterium dilution in premature infants

Rory J. Peppard, Cheryl A. Karn, M. Alan McCabe, Stephen R. Wassall, Edward A. Liechty, Scott Denne

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To assess whether a simple nonrestrictive method of determining nutrient intake could be applied to premature infants, we compared actual measured formula intake during a 7-day period with intake calculated from deuterium dilution in 13 hospitalized, growing, premature newborn infants. An oral dose of deuterium oxide (D2O) was administered, and urine samples were analyzed by deuterium nuclear magnetic resonance spectrometry for D2O concentration. Using an exponential model, we calculated formula intake from the decline in D2O concentration during the 7-day study period. Intake as assessed by the deuterium model correlated well with actual intake (r=0.93; p<0.001). However, because the deuterium dilution model measures both dietary and nondietary water intake (metabolic and cutaneous water influx), deuterium dilution-derived intake exceeded actual intake by 25±18 ml/kg per day (16%±11%). When corrections were applied to account for nondietary water intake, deuterium dilution-derived nutrient intake (160±30 ml/kg per day) closely approximated actual intake (155±17 ml/kg per day). If corrections are made for nondietary water intake, the deuterium dilution method may be a useful nonrestrictive method of measuring nutrient intake in a variety of neonatal populations.

Original languageEnglish
Pages (from-to)457-462
Number of pages6
JournalJournal of Pediatrics
Volume123
Issue number3
DOIs
StatePublished - 1993

Fingerprint

Deuterium
Premature Infants
Food
Drinking
Deuterium Oxide
Spectrum Analysis
Magnetic Resonance Spectroscopy
Urine
Newborn Infant
Skin
Water
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Peppard, R. J., Karn, C. A., McCabe, M. A., Wassall, S. R., Liechty, E. A., & Denne, S. (1993). Measurement of nutrient intake by deuterium dilution in premature infants. Journal of Pediatrics, 123(3), 457-462. https://doi.org/10.1016/S0022-3476(05)81756-1

Measurement of nutrient intake by deuterium dilution in premature infants. / Peppard, Rory J.; Karn, Cheryl A.; McCabe, M. Alan; Wassall, Stephen R.; Liechty, Edward A.; Denne, Scott.

In: Journal of Pediatrics, Vol. 123, No. 3, 1993, p. 457-462.

Research output: Contribution to journalArticle

Peppard, RJ, Karn, CA, McCabe, MA, Wassall, SR, Liechty, EA & Denne, S 1993, 'Measurement of nutrient intake by deuterium dilution in premature infants', Journal of Pediatrics, vol. 123, no. 3, pp. 457-462. https://doi.org/10.1016/S0022-3476(05)81756-1
Peppard, Rory J. ; Karn, Cheryl A. ; McCabe, M. Alan ; Wassall, Stephen R. ; Liechty, Edward A. ; Denne, Scott. / Measurement of nutrient intake by deuterium dilution in premature infants. In: Journal of Pediatrics. 1993 ; Vol. 123, No. 3. pp. 457-462.
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