Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers

Andres Castillo, Conrado J. Llapur, Tanya Martinez, Jeff Kisling, Tamica Williams-Nkomo, Cathy Coates, Robert Tepper

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We describe a method for measuring carbon monoxide diffusing capacity (DLCO) and alveolar volume (VA) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with room air to a lung volume with an airway pressure of 30 cmH2O (V30) inhibit inspiratory effort. The respiratory system is then inflated with a test gas containing helium and a stable isotope of carbon monoxide (C18O), and a respiratory pause is maintained for 4 sec and followed by passive expiration to functional residual capacity. Concentrations of helium and C18O are continuously measured with a mass spectrometer. Twelve healthy infants between 6-22 months of age were evaluated. For 9 of 12 subjects, duplicate measurements of alveolar volume at 30 cmH2O (VA30) and DLCO were within 10%, which are the recommendations for older children and adults. Among these 9 subjects, values of VA30 and DLCO increased with increasing body length (r2 = 0.82 and 0.79, respectively). The remaining 3 subjects had two values within 10-15%. Measurement of VA and DLCO with the single breath-hold technique at an elevated lung volume offers the potential to assess growth and development of the lung parenchyma early in life.

Original languageEnglish
Pages (from-to)544-550
Number of pages7
JournalPediatric Pulmonology
Volume41
Issue number6
DOIs
StatePublished - Jun 2006

Fingerprint

Carbon Monoxide
Respiratory System
Helium
Lung
Functional Residual Capacity
Economic Inflation
Growth and Development
Isotopes
Gases
Air
Pressure

Keywords

  • Alveolar volume
  • Diffusing capacity
  • Lung growth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Castillo, A., Llapur, C. J., Martinez, T., Kisling, J., Williams-Nkomo, T., Coates, C., & Tepper, R. (2006). Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers. Pediatric Pulmonology, 41(6), 544-550. https://doi.org/10.1002/ppul.20403

Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers. / Castillo, Andres; Llapur, Conrado J.; Martinez, Tanya; Kisling, Jeff; Williams-Nkomo, Tamica; Coates, Cathy; Tepper, Robert.

In: Pediatric Pulmonology, Vol. 41, No. 6, 06.2006, p. 544-550.

Research output: Contribution to journalArticle

Castillo, A, Llapur, CJ, Martinez, T, Kisling, J, Williams-Nkomo, T, Coates, C & Tepper, R 2006, 'Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers', Pediatric Pulmonology, vol. 41, no. 6, pp. 544-550. https://doi.org/10.1002/ppul.20403
Castillo A, Llapur CJ, Martinez T, Kisling J, Williams-Nkomo T, Coates C et al. Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers. Pediatric Pulmonology. 2006 Jun;41(6):544-550. https://doi.org/10.1002/ppul.20403
Castillo, Andres ; Llapur, Conrado J. ; Martinez, Tanya ; Kisling, Jeff ; Williams-Nkomo, Tamica ; Coates, Cathy ; Tepper, Robert. / Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers. In: Pediatric Pulmonology. 2006 ; Vol. 41, No. 6. pp. 544-550.
@article{8bef90f107ad45558368205359a678e3,
title = "Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers",
abstract = "We describe a method for measuring carbon monoxide diffusing capacity (DLCO) and alveolar volume (VA) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with room air to a lung volume with an airway pressure of 30 cmH2O (V30) inhibit inspiratory effort. The respiratory system is then inflated with a test gas containing helium and a stable isotope of carbon monoxide (C18O), and a respiratory pause is maintained for 4 sec and followed by passive expiration to functional residual capacity. Concentrations of helium and C18O are continuously measured with a mass spectrometer. Twelve healthy infants between 6-22 months of age were evaluated. For 9 of 12 subjects, duplicate measurements of alveolar volume at 30 cmH2O (VA30) and DLCO were within 10{\%}, which are the recommendations for older children and adults. Among these 9 subjects, values of VA30 and DLCO increased with increasing body length (r2 = 0.82 and 0.79, respectively). The remaining 3 subjects had two values within 10-15{\%}. Measurement of VA and DLCO with the single breath-hold technique at an elevated lung volume offers the potential to assess growth and development of the lung parenchyma early in life.",
keywords = "Alveolar volume, Diffusing capacity, Lung growth",
author = "Andres Castillo and Llapur, {Conrado J.} and Tanya Martinez and Jeff Kisling and Tamica Williams-Nkomo and Cathy Coates and Robert Tepper",
year = "2006",
month = "6",
doi = "10.1002/ppul.20403",
language = "English",
volume = "41",
pages = "544--550",
journal = "Pediatric Pulmonology",
issn = "8755-6863",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers

AU - Castillo, Andres

AU - Llapur, Conrado J.

AU - Martinez, Tanya

AU - Kisling, Jeff

AU - Williams-Nkomo, Tamica

AU - Coates, Cathy

AU - Tepper, Robert

PY - 2006/6

Y1 - 2006/6

N2 - We describe a method for measuring carbon monoxide diffusing capacity (DLCO) and alveolar volume (VA) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with room air to a lung volume with an airway pressure of 30 cmH2O (V30) inhibit inspiratory effort. The respiratory system is then inflated with a test gas containing helium and a stable isotope of carbon monoxide (C18O), and a respiratory pause is maintained for 4 sec and followed by passive expiration to functional residual capacity. Concentrations of helium and C18O are continuously measured with a mass spectrometer. Twelve healthy infants between 6-22 months of age were evaluated. For 9 of 12 subjects, duplicate measurements of alveolar volume at 30 cmH2O (VA30) and DLCO were within 10%, which are the recommendations for older children and adults. Among these 9 subjects, values of VA30 and DLCO increased with increasing body length (r2 = 0.82 and 0.79, respectively). The remaining 3 subjects had two values within 10-15%. Measurement of VA and DLCO with the single breath-hold technique at an elevated lung volume offers the potential to assess growth and development of the lung parenchyma early in life.

AB - We describe a method for measuring carbon monoxide diffusing capacity (DLCO) and alveolar volume (VA) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with room air to a lung volume with an airway pressure of 30 cmH2O (V30) inhibit inspiratory effort. The respiratory system is then inflated with a test gas containing helium and a stable isotope of carbon monoxide (C18O), and a respiratory pause is maintained for 4 sec and followed by passive expiration to functional residual capacity. Concentrations of helium and C18O are continuously measured with a mass spectrometer. Twelve healthy infants between 6-22 months of age were evaluated. For 9 of 12 subjects, duplicate measurements of alveolar volume at 30 cmH2O (VA30) and DLCO were within 10%, which are the recommendations for older children and adults. Among these 9 subjects, values of VA30 and DLCO increased with increasing body length (r2 = 0.82 and 0.79, respectively). The remaining 3 subjects had two values within 10-15%. Measurement of VA and DLCO with the single breath-hold technique at an elevated lung volume offers the potential to assess growth and development of the lung parenchyma early in life.

KW - Alveolar volume

KW - Diffusing capacity

KW - Lung growth

UR - http://www.scopus.com/inward/record.url?scp=33744483999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744483999&partnerID=8YFLogxK

U2 - 10.1002/ppul.20403

DO - 10.1002/ppul.20403

M3 - Article

C2 - 16617450

AN - SCOPUS:33744483999

VL - 41

SP - 544

EP - 550

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

IS - 6

ER -