Measuring and interpreting ocular blood flow and metabolism in glaucoma

Alon Harris, Larry Kagemann, Rita Ehrlich, Carlos Rospigliosi, Danny Moore, Brent Siesky

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

There is a growing body of evidence suggesting that vascular dysfunction is related to several prominent ophthalmic diseases, including glaucoma. The vast majority of studies providing data on ocular circulation and disease pathophysiology use a relatively small number of complicated ocular blood flow imaging techniques. Although these imaging technologies are not commonly used in clinical settings, understanding the medical literature characterizing ocular blood flow requires familiarity with their methodology and function. This review highlights the imaging technologies most commonly used to investigate ocular blood flow, including color Doppler imaging, confocal scanning laser ophthalmoscopic angiography with fluorescein and indocyanine green dye, Canon laser blood flowmetry, scanning laser Doppler flowmetry, and retinal photographic oximetry. Each imaging technique's ability to define vascular function and reveal pathology is discussed as are limitations inherent to each technology. The ultimate goal of this review is to provide the physician with a clinically relevant foundation for differentiating the various ocular blood flow outcome measures often presented in the literature and determine how they are related to ocular health and disease.

Original languageEnglish
Pages (from-to)328-336
Number of pages9
JournalCanadian Journal of Ophthalmology
Volume43
Issue number3
DOIs
StatePublished - 2008

Fingerprint

Glaucoma
Eye Diseases
Technology
Blood Vessels
Dye Lasers
Laser-Doppler Flowmetry
Aptitude
Indocyanine Green
Oximetry
Rheology
Fluorescein Angiography
Lasers
Color
Outcome Assessment (Health Care)
Pathology
Physicians
Health

Keywords

  • Glaucoma
  • Imaging technologies
  • Ocular blood flow

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Measuring and interpreting ocular blood flow and metabolism in glaucoma. / Harris, Alon; Kagemann, Larry; Ehrlich, Rita; Rospigliosi, Carlos; Moore, Danny; Siesky, Brent.

In: Canadian Journal of Ophthalmology, Vol. 43, No. 3, 2008, p. 328-336.

Research output: Contribution to journalArticle

Harris, Alon ; Kagemann, Larry ; Ehrlich, Rita ; Rospigliosi, Carlos ; Moore, Danny ; Siesky, Brent. / Measuring and interpreting ocular blood flow and metabolism in glaucoma. In: Canadian Journal of Ophthalmology. 2008 ; Vol. 43, No. 3. pp. 328-336.
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