Measuring blood delivery to solitary pulmonary nodules using perfusion magnetic resonance imaging

Wei Zheng, Zhifeng Wang, Li Shen, Ling Gao, James C. Ford, Fillia S. Makedon, Justin D. Pearlman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

With perfusion magnetic resonance imaging (pMRI), perfusion describes the amount of blood passing through a block of tissue in a certain period of time. In pMRI, the tissue having more blood passing through will show higher intensity value as more contrast-labeled blood arrives. Perfusion reflects the delivery of essential nutrients to a block of tissue, and is an important parameter for the tissue status. Considering solitary pulmonary nodules (SPN), perfusion differences between malignant and benign nodules have been studied by different techniques. Much effort has been put into its characterization. In this paper, we proposed and implemented extraction of the SPN time intensity profile to measure blood delivery to solitary pulmonary nodules, describing their perfusion effects. In this method, a SPN time intensity profile is created based on intensity values of the solitary pulmonary nodule in lung pMRI images over time. This method has two steps: nodule tracking and profile clustering. Nodule tracking aligns the solitary pulmonary nodule in pMRI images taken at different time points, dealing with nodule movement resulted from breathing and body movement. Profile clustering implements segmentation of the nodule region and extraction of the time intensity profile of a solitary pulmonary nodule. SPN time intensity profiles reflect patterns of blood delivery to solitary pulmonary nodules, giving us a description of perfusion effect and indirect evidence of tumor angiogenesis. Analysis on SPN time intensity profiles will help the diagnosis of malignant nodules for early lung cancer detection.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2006
Subtitle of host publicationPhysiology, Function, and Structure from Medical Images
DOIs
StatePublished - Jul 3 2006
Externally publishedYes
EventMedical Imaging 2006: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 12 2006Feb 14 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6143 II
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2006: Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/12/062/14/06

Keywords

  • Blood delivery
  • Solitary pulmonary nodule
  • Time intensity profile
  • pMRI

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Zheng, W., Wang, Z., Shen, L., Gao, L., Ford, J. C., Makedon, F. S., & Pearlman, J. D. (2006). Measuring blood delivery to solitary pulmonary nodules using perfusion magnetic resonance imaging. In Medical Imaging 2006: Physiology, Function, and Structure from Medical Images [614332] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6143 II). https://doi.org/10.1117/12.652866