Measuring cholinergic sensitivity: I. Arecoline effects in bipolar patients

John Nurnberger, Wade Berrettini, Wallace Mendelson, David Sack, Elliot S. Gershon

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In a previous study, bipolar patients were found to be more sensitive than controls to induction of rapid eye movement (REM) sleep by the direct muscarinic agonist arecoline. We have replicated this observation in a new group of patients and controls. However, much overlap between groups was seen. Muscarinic supersensitivity appears to be present in some bipolar affective patients, but the REM induction procedure may not be the optimal method for measuring it.

Original languageEnglish (US)
Pages (from-to)610-617
Number of pages8
JournalBiological Psychiatry
Volume25
Issue number5
DOIs
StatePublished - Mar 1 1989
Externally publishedYes

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Arecoline
Cholinergic Agents
REM Sleep
Muscarinic Agonists
Sleep
Control Groups

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Measuring cholinergic sensitivity : I. Arecoline effects in bipolar patients. / Nurnberger, John; Berrettini, Wade; Mendelson, Wallace; Sack, David; Gershon, Elliot S.

In: Biological Psychiatry, Vol. 25, No. 5, 01.03.1989, p. 610-617.

Research output: Contribution to journalArticle

Nurnberger, John ; Berrettini, Wade ; Mendelson, Wallace ; Sack, David ; Gershon, Elliot S. / Measuring cholinergic sensitivity : I. Arecoline effects in bipolar patients. In: Biological Psychiatry. 1989 ; Vol. 25, No. 5. pp. 610-617.
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