Measuring cholinergic sensitivity: I. Arecoline effects in bipolar patients

John Nurnberger, Wade Berrettini, Wallace Mendelson, David Sack, Elliot S. Gershon

Research output: Contribution to journalArticle

31 Scopus citations


In a previous study, bipolar patients were found to be more sensitive than controls to induction of rapid eye movement (REM) sleep by the direct muscarinic agonist arecoline. We have replicated this observation in a new group of patients and controls. However, much overlap between groups was seen. Muscarinic supersensitivity appears to be present in some bipolar affective patients, but the REM induction procedure may not be the optimal method for measuring it.

Original languageEnglish (US)
Pages (from-to)610-617
Number of pages8
JournalBiological psychiatry
Issue number5
StatePublished - Mar 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry

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