Measuring cholinergic sensitivity: II. Arecoline effects on metabolic activity in pontine regions of rat brain

Timothy T. Soncrant, John Nurnberger

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Brain imaging studies may help to localize areas particularly sensitive to cholinergic agonists. A study in rats using the 2-deoxyglucose method for studying changes in brain metabolic activity was performed. Among regions in the pons/medulla, arecoline, 0.05 mg/kg ip, increased glucose utilization in the dorsal raphe, median raphe, and basilar pontine nuclei without producing behavioral or cardiovascular effects. These brain areas, along with the hippocampus, may be pertinent to studies of muscarinic supersensitivity in humans.

Original languageEnglish (US)
Pages (from-to)618-625
Number of pages8
JournalBiological psychiatry
Volume25
Issue number5
DOIs
StatePublished - Mar 1 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Biological Psychiatry

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