Measuring cholinergic sensitivity

II. Arecoline effects on metabolic activity in pontine regions of rat brain

Timothy T. Soncrant, John Nurnberger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Brain imaging studies may help to localize areas particularly sensitive to cholinergic agonists. A study in rats using the 2-deoxyglucose method for studying changes in brain metabolic activity was performed. Among regions in the pons/medulla, arecoline, 0.05 mg/kg ip, increased glucose utilization in the dorsal raphe, median raphe, and basilar pontine nuclei without producing behavioral or cardiovascular effects. These brain areas, along with the hippocampus, may be pertinent to studies of muscarinic supersensitivity in humans.

Original languageEnglish (US)
Pages (from-to)618-625
Number of pages8
JournalBiological Psychiatry
Volume25
Issue number5
DOIs
StatePublished - Mar 1 1989
Externally publishedYes

Fingerprint

Arecoline
Cholinergic Agents
Cholinergic Agonists
Pons
Deoxyglucose
Brain
Neuroimaging
Hippocampus
Glucose

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Measuring cholinergic sensitivity : II. Arecoline effects on metabolic activity in pontine regions of rat brain. / Soncrant, Timothy T.; Nurnberger, John.

In: Biological Psychiatry, Vol. 25, No. 5, 01.03.1989, p. 618-625.

Research output: Contribution to journalArticle

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