Measuring ethanol-seeking behavior: The effect of using repeated extinction trials

HermanH H. Samson, Ann Chappell, Cristine Czachowski, Amanda Sharpe

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The development of a reliable measure of the level of ethanol-seeking behavior in an animal model is important to understanding the concept of craving. However, most existing models do not allow for the separation of the behavior associated with obtaining ethanol from that involved in consumption of ethanol. In this study, we determined the ability of repeated, single-session extinction tests in an appetitive and consummatory procedure of ethanol self-administration to assess the level of seeking behavior. The findings indicated that there were no major effects of previous extinction trials on later trials, when there were at least four reinforced sessions between tests. During reinforced sessions, the rats were consuming an average of 0.80 g of ethanol per kilogram of body weight in less than 20 min from a sipper tube. In addition, the amount of extinction responding was found to be similar to a previous measure of the appetitive strength of ethanol by using a breakpoint procedure. This method of repeated extinction tests seems to be valuable for examining the effects of pharmacological treatments that might alter ethanol seeking.

Original languageEnglish (US)
Pages (from-to)205-209
Number of pages5
JournalAlcohol
Volume24
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Ethanol
self-administration
body weight
animal
ability
Aptitude
Self Administration
Psychological Extinction
Rats
Animals
Animal Models
Body Weight
Pharmacology

Keywords

  • Alcohol
  • Appetitive behavior
  • Rats

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neuroscience(all)
  • Toxicology
  • Health(social science)

Cite this

Measuring ethanol-seeking behavior : The effect of using repeated extinction trials. / Samson, HermanH H.; Chappell, Ann; Czachowski, Cristine; Sharpe, Amanda.

In: Alcohol, Vol. 24, No. 3, 2001, p. 205-209.

Research output: Contribution to journalArticle

Samson, HH, Chappell, A, Czachowski, C & Sharpe, A 2001, 'Measuring ethanol-seeking behavior: The effect of using repeated extinction trials', Alcohol, vol. 24, no. 3, pp. 205-209. https://doi.org/10.1016/S0741-8329(01)00157-4
Samson, HermanH H. ; Chappell, Ann ; Czachowski, Cristine ; Sharpe, Amanda. / Measuring ethanol-seeking behavior : The effect of using repeated extinction trials. In: Alcohol. 2001 ; Vol. 24, No. 3. pp. 205-209.
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