Mechanical determinants of osteoarthrosis

E. L. Radin, David Burr, B. Caterson, D. Fyhrie, T. D. Brown, R. D. Boyd

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

The joint is an organ and functions as a mechanical bearing created of biological materials. In the joint, as in all connective tissues, there is a relationship between mechanical factors and tissue behavior. Therefore, it is not surprising that joint health and osteoarthrosis are reflections of both mechanical and biological factors. Osteoarthrosis is not a disease, but organ failure caused initially by mechanical factors. The biological changes follow. There is no habitual pathophysiological cascade. Osteoarthrosis is best thought of not as a common final pathway, but as a common end stage. The hypotheses that in osteoarthrosis substructural disorganization of the matrix proceeds chondrocytic enzyme production, that impulsive loading is an essential factor in the progressive cartilage destruction, and that tidemark advancement and horizontal cartilage splitting are the primary mechanisms in progressive cartilage loss are discussed.

Original languageEnglish
Pages (from-to)12-21
Number of pages10
JournalSeminars in Arthritis and Rheumatism
Volume21
Issue number3 SUPPL. 2
DOIs
StatePublished - 1991

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Osteoarthritis
Cartilage
Joints
Biological Factors
Thromboplastin
Connective Tissue
Health
Enzymes

Keywords

  • articular cartilage loss
  • degenerative joint disease
  • joint damage
  • Osteoarthrosis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Radin, E. L., Burr, D., Caterson, B., Fyhrie, D., Brown, T. D., & Boyd, R. D. (1991). Mechanical determinants of osteoarthrosis. Seminars in Arthritis and Rheumatism, 21(3 SUPPL. 2), 12-21. https://doi.org/10.1016/0049-0172(91)90036-Y

Mechanical determinants of osteoarthrosis. / Radin, E. L.; Burr, David; Caterson, B.; Fyhrie, D.; Brown, T. D.; Boyd, R. D.

In: Seminars in Arthritis and Rheumatism, Vol. 21, No. 3 SUPPL. 2, 1991, p. 12-21.

Research output: Contribution to journalArticle

Radin, EL, Burr, D, Caterson, B, Fyhrie, D, Brown, TD & Boyd, RD 1991, 'Mechanical determinants of osteoarthrosis', Seminars in Arthritis and Rheumatism, vol. 21, no. 3 SUPPL. 2, pp. 12-21. https://doi.org/10.1016/0049-0172(91)90036-Y
Radin EL, Burr D, Caterson B, Fyhrie D, Brown TD, Boyd RD. Mechanical determinants of osteoarthrosis. Seminars in Arthritis and Rheumatism. 1991;21(3 SUPPL. 2):12-21. https://doi.org/10.1016/0049-0172(91)90036-Y
Radin, E. L. ; Burr, David ; Caterson, B. ; Fyhrie, D. ; Brown, T. D. ; Boyd, R. D. / Mechanical determinants of osteoarthrosis. In: Seminars in Arthritis and Rheumatism. 1991 ; Vol. 21, No. 3 SUPPL. 2. pp. 12-21.
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