Mechanical thrombolysis of venous thrombosis in an animal model with use of temporary caval filtration

Scott O. Trerotola, Gordon McLennan, Anthony C. Eclavea, Ari Salis, Darrell Davidson, R. Gerald Dreesen, Jerry Tennery

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

PURPOSE: To test the effect of temporary caval filtration on pulmonary emboli when a mechanical thrombolytic device is used to treat venous thrombosis and to test the effects of a modified device on caval patency at 30-day follow-up. MATERIALS AND METHODS: In a canine model of iliocaval subacute thrombosis, mechanical thrombolysis was performed with use of an 8-F over-the-wire Arrow-Trerotola Percutaneous Thrombolytic Device (PTD) with a 9-mm (iliac) or 15-mm (inferior vena cava [IVC]) basket. In six procedures, the device was made of nitinol monofilament, and in another six, it was made of braided stainless steel. All procedures were performed with a nitinol expandable sheath (temporary filter) in the suprarenal IVC. Low-molecular-weight heparin was given daily after the procedure. Venography, pulmonary arteriography, measurement of blood gases, and pulmonary artery (PA) pressure measurement were performed before and after the procedure and at 30-day follow-up. Pulmonary arteriograms from the group treated with stainless-steel devices were compared to those from an earlier group of animals in which the identical procedure was performed without caval filtration. The IVC was examined histologically. RESULTS: Thrombolysis was successful in all animals. Rare segmental and subsegmental pulmonary emboli (PE) were seen arteriographically; compared to procedures without filters, there was a significant reduction in PE (P < .002). However, a mild increase in pulmonary artery pressure, decrease in pH, and increase in pCO2 were observed postprocedurally. At 30-day follow-up (n = 11), IVC patency was preserved in 45% (n = 5) of animals overall. Caval patency was significantly better in animals in which the combination of stainless-steel devices was used (five of six = 83% vs zero with nitinol device; P = .015). Histologically, the stainless-steel device caused little intimal injury and fibrosis - less than that seen with the nitinol device. CONCLUSIONS: Temporary filtration reduces, but does not completely eliminate, PE during mechanical thrombolysis. The stainless-steel device results in less intimal injury and better caval patency than the nitinol device.

Original languageEnglish (US)
Pages (from-to)1075-1085
Number of pages11
JournalJournal of Vascular and Interventional Radiology
Volume12
Issue number9
DOIs
StatePublished - Sep 2001

Fingerprint

Mechanical Thrombolysis
Venae Cavae
Venous Thrombosis
Animal Models
Equipment and Supplies
Stainless Steel
Inferior Vena Cava
Embolism
Lung
Tunica Intima
Pulmonary Artery
Pressure
Phlebography
Low Molecular Weight Heparin
Wounds and Injuries

Keywords

  • Animal model
  • Thrombectomy
  • Veins, thrombosis
  • Venae cavae, filters

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Trerotola, S. O., McLennan, G., Eclavea, A. C., Salis, A., Davidson, D., Dreesen, R. G., & Tennery, J. (2001). Mechanical thrombolysis of venous thrombosis in an animal model with use of temporary caval filtration. Journal of Vascular and Interventional Radiology, 12(9), 1075-1085. https://doi.org/10.1016/S1051-0443(07)61595-4

Mechanical thrombolysis of venous thrombosis in an animal model with use of temporary caval filtration. / Trerotola, Scott O.; McLennan, Gordon; Eclavea, Anthony C.; Salis, Ari; Davidson, Darrell; Dreesen, R. Gerald; Tennery, Jerry.

In: Journal of Vascular and Interventional Radiology, Vol. 12, No. 9, 09.2001, p. 1075-1085.

Research output: Contribution to journalArticle

Trerotola, SO, McLennan, G, Eclavea, AC, Salis, A, Davidson, D, Dreesen, RG & Tennery, J 2001, 'Mechanical thrombolysis of venous thrombosis in an animal model with use of temporary caval filtration', Journal of Vascular and Interventional Radiology, vol. 12, no. 9, pp. 1075-1085. https://doi.org/10.1016/S1051-0443(07)61595-4
Trerotola, Scott O. ; McLennan, Gordon ; Eclavea, Anthony C. ; Salis, Ari ; Davidson, Darrell ; Dreesen, R. Gerald ; Tennery, Jerry. / Mechanical thrombolysis of venous thrombosis in an animal model with use of temporary caval filtration. In: Journal of Vascular and Interventional Radiology. 2001 ; Vol. 12, No. 9. pp. 1075-1085.
@article{169271baea194c57940925ad485f224d,
title = "Mechanical thrombolysis of venous thrombosis in an animal model with use of temporary caval filtration",
abstract = "PURPOSE: To test the effect of temporary caval filtration on pulmonary emboli when a mechanical thrombolytic device is used to treat venous thrombosis and to test the effects of a modified device on caval patency at 30-day follow-up. MATERIALS AND METHODS: In a canine model of iliocaval subacute thrombosis, mechanical thrombolysis was performed with use of an 8-F over-the-wire Arrow-Trerotola Percutaneous Thrombolytic Device (PTD) with a 9-mm (iliac) or 15-mm (inferior vena cava [IVC]) basket. In six procedures, the device was made of nitinol monofilament, and in another six, it was made of braided stainless steel. All procedures were performed with a nitinol expandable sheath (temporary filter) in the suprarenal IVC. Low-molecular-weight heparin was given daily after the procedure. Venography, pulmonary arteriography, measurement of blood gases, and pulmonary artery (PA) pressure measurement were performed before and after the procedure and at 30-day follow-up. Pulmonary arteriograms from the group treated with stainless-steel devices were compared to those from an earlier group of animals in which the identical procedure was performed without caval filtration. The IVC was examined histologically. RESULTS: Thrombolysis was successful in all animals. Rare segmental and subsegmental pulmonary emboli (PE) were seen arteriographically; compared to procedures without filters, there was a significant reduction in PE (P < .002). However, a mild increase in pulmonary artery pressure, decrease in pH, and increase in pCO2 were observed postprocedurally. At 30-day follow-up (n = 11), IVC patency was preserved in 45{\%} (n = 5) of animals overall. Caval patency was significantly better in animals in which the combination of stainless-steel devices was used (five of six = 83{\%} vs zero with nitinol device; P = .015). Histologically, the stainless-steel device caused little intimal injury and fibrosis - less than that seen with the nitinol device. CONCLUSIONS: Temporary filtration reduces, but does not completely eliminate, PE during mechanical thrombolysis. The stainless-steel device results in less intimal injury and better caval patency than the nitinol device.",
keywords = "Animal model, Thrombectomy, Veins, thrombosis, Venae cavae, filters",
author = "Trerotola, {Scott O.} and Gordon McLennan and Eclavea, {Anthony C.} and Ari Salis and Darrell Davidson and Dreesen, {R. Gerald} and Jerry Tennery",
year = "2001",
month = "9",
doi = "10.1016/S1051-0443(07)61595-4",
language = "English (US)",
volume = "12",
pages = "1075--1085",
journal = "Journal of Vascular and Interventional Radiology",
issn = "1051-0443",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Mechanical thrombolysis of venous thrombosis in an animal model with use of temporary caval filtration

AU - Trerotola, Scott O.

AU - McLennan, Gordon

AU - Eclavea, Anthony C.

AU - Salis, Ari

AU - Davidson, Darrell

AU - Dreesen, R. Gerald

AU - Tennery, Jerry

PY - 2001/9

Y1 - 2001/9

N2 - PURPOSE: To test the effect of temporary caval filtration on pulmonary emboli when a mechanical thrombolytic device is used to treat venous thrombosis and to test the effects of a modified device on caval patency at 30-day follow-up. MATERIALS AND METHODS: In a canine model of iliocaval subacute thrombosis, mechanical thrombolysis was performed with use of an 8-F over-the-wire Arrow-Trerotola Percutaneous Thrombolytic Device (PTD) with a 9-mm (iliac) or 15-mm (inferior vena cava [IVC]) basket. In six procedures, the device was made of nitinol monofilament, and in another six, it was made of braided stainless steel. All procedures were performed with a nitinol expandable sheath (temporary filter) in the suprarenal IVC. Low-molecular-weight heparin was given daily after the procedure. Venography, pulmonary arteriography, measurement of blood gases, and pulmonary artery (PA) pressure measurement were performed before and after the procedure and at 30-day follow-up. Pulmonary arteriograms from the group treated with stainless-steel devices were compared to those from an earlier group of animals in which the identical procedure was performed without caval filtration. The IVC was examined histologically. RESULTS: Thrombolysis was successful in all animals. Rare segmental and subsegmental pulmonary emboli (PE) were seen arteriographically; compared to procedures without filters, there was a significant reduction in PE (P < .002). However, a mild increase in pulmonary artery pressure, decrease in pH, and increase in pCO2 were observed postprocedurally. At 30-day follow-up (n = 11), IVC patency was preserved in 45% (n = 5) of animals overall. Caval patency was significantly better in animals in which the combination of stainless-steel devices was used (five of six = 83% vs zero with nitinol device; P = .015). Histologically, the stainless-steel device caused little intimal injury and fibrosis - less than that seen with the nitinol device. CONCLUSIONS: Temporary filtration reduces, but does not completely eliminate, PE during mechanical thrombolysis. The stainless-steel device results in less intimal injury and better caval patency than the nitinol device.

AB - PURPOSE: To test the effect of temporary caval filtration on pulmonary emboli when a mechanical thrombolytic device is used to treat venous thrombosis and to test the effects of a modified device on caval patency at 30-day follow-up. MATERIALS AND METHODS: In a canine model of iliocaval subacute thrombosis, mechanical thrombolysis was performed with use of an 8-F over-the-wire Arrow-Trerotola Percutaneous Thrombolytic Device (PTD) with a 9-mm (iliac) or 15-mm (inferior vena cava [IVC]) basket. In six procedures, the device was made of nitinol monofilament, and in another six, it was made of braided stainless steel. All procedures were performed with a nitinol expandable sheath (temporary filter) in the suprarenal IVC. Low-molecular-weight heparin was given daily after the procedure. Venography, pulmonary arteriography, measurement of blood gases, and pulmonary artery (PA) pressure measurement were performed before and after the procedure and at 30-day follow-up. Pulmonary arteriograms from the group treated with stainless-steel devices were compared to those from an earlier group of animals in which the identical procedure was performed without caval filtration. The IVC was examined histologically. RESULTS: Thrombolysis was successful in all animals. Rare segmental and subsegmental pulmonary emboli (PE) were seen arteriographically; compared to procedures without filters, there was a significant reduction in PE (P < .002). However, a mild increase in pulmonary artery pressure, decrease in pH, and increase in pCO2 were observed postprocedurally. At 30-day follow-up (n = 11), IVC patency was preserved in 45% (n = 5) of animals overall. Caval patency was significantly better in animals in which the combination of stainless-steel devices was used (five of six = 83% vs zero with nitinol device; P = .015). Histologically, the stainless-steel device caused little intimal injury and fibrosis - less than that seen with the nitinol device. CONCLUSIONS: Temporary filtration reduces, but does not completely eliminate, PE during mechanical thrombolysis. The stainless-steel device results in less intimal injury and better caval patency than the nitinol device.

KW - Animal model

KW - Thrombectomy

KW - Veins, thrombosis

KW - Venae cavae, filters

UR - http://www.scopus.com/inward/record.url?scp=0034839633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034839633&partnerID=8YFLogxK

U2 - 10.1016/S1051-0443(07)61595-4

DO - 10.1016/S1051-0443(07)61595-4

M3 - Article

C2 - 11535771

AN - SCOPUS:0034839633

VL - 12

SP - 1075

EP - 1085

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 9

ER -