Mechanism of bicarbonate secretion in rat (Rattus rattus) colon

Pierre C. Dagher, John I. Rho, Alan N. Charney

Research output: Contribution to journalArticle

8 Scopus citations


1. 1. Colonie HCO3 secretion was measured as the residual flux in male Sprague-Dawley rats (Rattus rattus). 2. 2. Basal HCO3 secretion was increased by 1 mM dibutyryl cyclic AMP (dbcAMP) and was reduced to baseline by 0.1 mM methazolamide (Mtz) but not by SITS (1 mM), DIDS (1 mM) or amiloride (1 mM). 3. 3. In vivo, intravenous vasoactive intestinal peptide increased HCO3 secretion and prior perfusion with 1 mM Mtz prevented this increase. 4. 4. These results suggest that the source of basal and cAMP-stimulated HCO3 secretion is, in part, intracellular and requires the action of carbonic anhydrase.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Issue number1
StatePublished - May 1993

ASJC Scopus subject areas

  • Physiology

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