Mechanism of exercise-induced ocular hypotension

Bruce Martin, Alon Harris, Ted Hammel, Vic Malinovsky

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

PURPOSE. Although acute dynamic exercise reduces intraocular pressure (IOP), the factors that provoke this response remain ill-defined. To determine whether changes in colloid osmotic pressure (COP) cause the IOP changes during exercise, standardized exercise was performed after dehydration and hydration with isosmotic fluid. METHODS. Progressive cycle ergometer exercise to volitional exhaustion was performed after 4 hours' dehydration, and after hydration with 946 ml isosmotic liquid (345 mOsM). In each experiment, venous blood taken before and immediately after exercise was analyzed for hematocrit, plasma protein concentration, total plasma osmolality, and plasma COP. RESULTS. Exercise in both experiments significantly reduced IOP and elevated COP (each P < 0.01). Dehydration, compared with hydration, also significantly reduced IOP and elevated COP, when measured before and after exercise (P < 0.05). The correlation of mean IOP with mean COP, over the entire range created by varying exercise and hydration statuses, was statistically significant (r = -0.99; P < 0.001). In contrast, other indexes of hydration status, including hematocrit, total plasma osmolality, and plasma protein concentration, failed to change as IOP changed and failed to correlate with IOP, on either a group or individual basis, in conditions of varying levels of exercise and hydration. CONCLUSIONS. Acute dynamic exercise and isosmotic fluid ingestion each seem to change IOP through changes in COP.

Original languageEnglish (US)
Pages (from-to)1011-1015
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume40
Issue number5
StatePublished - Apr 13 1999
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Martin, B., Harris, A., Hammel, T., & Malinovsky, V. (1999). Mechanism of exercise-induced ocular hypotension. Investigative Ophthalmology and Visual Science, 40(5), 1011-1015.